Abstract Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter known to affect
emotion, behavior, and cognition, and its effects are mostly studied in neurological diseases …

Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …

Although typically considered a neurotransmitter, there is substantial evidence that serotonin
(5-HT) plays an important role in the pathogenesis of inflammatory disorders. Despite these …

The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the
blood-brain barrier renders potentially druggable amplified or mutated oncoproteins …

The nervous system plays a central role in regulating the stem cell niche in many organs,
and thereby pivotally modulates development, homeostasis, and plasticity. A similarly …

Homeostatic control of volume within the alveolar spaces of the mammary gland has been
proposed to involve a feedback system mediated by serotonin signaling. In this article, we …

Highlights•Neuronal activity promotes glioma growth.•Gliomas increase neuronal excitability
and promote seizures.•Bidirectional communication between gliomas and neurons in the …

Perineuronal satellitosis, the microanatomical clustering of glioma cells around neurons in
the tumor microenvironment, has been recognized as a histopathological hallmark of high …

Mammary gland homeostasis and the lactation-to-involution switch are regulated by
serotonin (5-hydroxytryptamine (5-HT)). Mammary epithelial tight junctions are physiological …

Anti-psychotic medications are widely used to treat schizophrenia and bipolar disorder.
Besides their medical applications, anti-psychotic drugs have other pharmacological …