Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …

This review deals with emerging evidence of an association between systemic or local
hypoxia and inflammation in a variety of diseases. The evidence points to new ways of …

Adaptation of cancer cells to their microenvironment is an important driving force in the
clonal selection that leads to invasive and metastatic disease. O 2 concentrations are …

Hypoxia-inducible factor 1 (HIF-1) plays a key role in the reprogramming of cancer
metabolism by activating transcription of genes encoding glucose transporters and glycolytic …

Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors,
HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐and metastasis‐initiating …

Abstract Myeloid Derived Suppressor Cells (MDSC) are a heterogeneous population of
immature myeloid cells that are increased in states of cancer, inflammation and infection. In …

Prostate cancer is a main urological disease associated with significant morbidity and
mortality. Radical prostatectomy and radiotherapy are potentially curative for localized …

Significance: Cancer is a complex disease, which not only involves the tumor but its
microenvironment comprising different immune cells as well. Nitric oxide (NO) plays specific …

High Gleason grade prostate carcinomas are aggressive, poorly differentiated tumors that
exhibit diminished estrogen receptor β (ERβ) expression. We report that a key function of …

Glycolysis is a typical conduit for energy metabolism in pancreatic cancer (PC) due to the
hypoxic microenviroment. Lactate dehydrogenase A (LDHA) catalyzes the conversion of …