There is extensive experimental evidence that oxidative damage permanently occurs to
lipids of cellular membranes, proteins, and DNA. In nuclear and mitochondrial DNA, 8 …

8-hydroxy-2′-deoxyguanosine (8-OH-dG) was first reported in 1984 as a major form of
oxidative DNA damage product by heated sugar, Fenton-type reagents and X-irradiation in …

Oxygen derived species such as superoxide radical, hydrogen peroxide, singlet oxygen and
hydroxyl radical are well known to be cytotoxic and have been implicated in the etiology of a …

Exposure to ambient air particulate matter (PM) is associated with pulmonary and
cardiovascular diseases and cancer. The mechanisms of PM-induced health effects are …

In living cells reactive oxygen species (ROS) are formed continuously as a consequence of
metabolic and other biochemical reactions as well as external factors. Some ROS have …

Combustion emissions account for over half of the fine particle (PM2. 5) air pollution and
most of the primary particulate organic matter. Human exposure to combustion emissions …

Particulates are small particles of solid or liquid suspended in liquid or air. In vitro studies
show that particles generate reactive oxygen species, deplete endogenous antioxidants …

Large cohort studies in the US and in Europe suggest that air pollution may increase lung
cancer risk. Biomarkers can be useful to understand the mechanisms and to characterize …

Oxygen free radicals and their metabolites, collectively described as reactive oxygen
species (ROS), have been implicated in the pathogenesis of many diseases. The pulmonary …

To evaluate the effect of cigarette smoking on oxidative stress in lung tissues, we compared
the levels of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OH-dG), in …