Investigation of human trophoblast invasion in vitro
BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …
Liver organoids: from basic research to therapeutic applications
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a
dish. While mouse models and cell lines have furthered our understanding of liver biology …
dish. While mouse models and cell lines have furthered our understanding of liver biology …
Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity
DJ Richards, Y Li, CM Kerr, J Yao, GC Beeson… - Nature biomedical …, 2020 - nature.com
Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …
Disease modeling using 3D organoids derived from human induced pluripotent stem cells
The rising interest in human induced pluripotent stem cell (hiPSC)-derived organoid culture
has stemmed from the manipulation of various combinations of directed multi-lineage …
has stemmed from the manipulation of various combinations of directed multi-lineage …
Ontogeny of hepatic transporters and drug-metabolizing enzymes in humans and in nonclinical species
BD Van Groen, J Nicolaï, AC Kuik… - Pharmacological …, 2021 - ASPET
The liver represents a major eliminating and detoxifying organ, determining exposure to
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …
Concise review: current status of three-dimensional organoids as preclinical models
Abstract Three-dimensional (3D) cultures use the property of some cells to self-organize in
matrices and generate structures that can be programmed to represent an organ or a …
matrices and generate structures that can be programmed to represent an organ or a …
The use of stem cell-derived organoids in disease modeling: an update
Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …
during the past decade. They are three-dimensional in vitro culturing models that originate …
HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models
J Torresi, BM Tran, D Christiansen, L Earnest-Silveira… - Bmc Cancer, 2019 - Springer
Abstract Background Hepatitis B virus (HBV) is the leading cause of liver cancer, but the
mechanisms by which HBV causes liver cancer are poorly understood and …
mechanisms by which HBV causes liver cancer are poorly understood and …
Recent advances in organoid engineering: A comprehensive review
JM Unagolla, AC Jayasuriya - Applied materials today, 2022 - Elsevier
Organoid, a 3D structure derived from various cell sources including progenitor and
differentiated cells that self-organize through cell-cell and cell-matrix interactions to …
differentiated cells that self-organize through cell-cell and cell-matrix interactions to …
Liver organoid as a 3D in vitro model for drug validation and toxicity assessment
A Brooks, X Liang, Y Zhang, CX Zhao… - Pharmacological …, 2021 - Elsevier
The past decade has seen many advancements in the development of three-dimensional
(3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present …
(3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present …