Divorcing ARF and p53: an unsettled case
CJ Sherr - Nature Reviews Cancer, 2006 - nature.com
Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …
either halt their division or trigger their apoptosis, but these countermeasures must be finely …
Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function
C Korgaonkar, J Hagen, V Tompkins… - … and cellular biology, 2005 - Taylor & Francis
The ARF tumor suppressor is a nucleolar protein that activates p53-dependent checkpoints
by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and …
by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and …
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia
Chronic myeloid leukemia (CML) is induced by the oncogenic BCR-ABL1 tyrosine kinase
and can be effectively treated for many years with tyrosine kinase inhibitors (TKIs). However …
and can be effectively treated for many years with tyrosine kinase inhibitors (TKIs). However …
[HTML][HTML] Ischemic and non-ischemic acute kidney injury cause hepatic damage
Recent studies have documented that remote organs are affected by ischemic injury to the
kidney. Here we studied whether the liver also suffers damage during induction of renal …
kidney. Here we studied whether the liver also suffers damage during induction of renal …
Human tumor suppressor p53 and DNA viruses
S Collot‐Teixeira, J Bass, F Denis… - Reviews in medical …, 2004 - Wiley Online Library
Human tumor suppressor protein p53 plays a major role in the cell cycle, orchestrating a
number of important genes involved in cell‐cycle control and apoptosis, and seems to be …
number of important genes involved in cell‐cycle control and apoptosis, and seems to be …
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides
SC Kaul, S Aida, T Yaguchi, K Kaur… - Journal of Biological …, 2005 - ASBMB
The Hsp70 family member mortalin (mot-2/mthsp70/GRP75) binds to a carboxyl terminus
region of the tumor suppressor protein p53. By in vivo co-immunoprecipitation of mot-2 with …
region of the tumor suppressor protein p53. By in vivo co-immunoprecipitation of mot-2 with …
Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells
We screened some phytochemicals for cytotoxic activity to human cancer cells and identified
Soyasapogenol-A (Snol-A) as a potent candidate anti-cancer compound. Interestingly …
Soyasapogenol-A (Snol-A) as a potent candidate anti-cancer compound. Interestingly …
LncRNA SAMMSON mediates adaptive resistance to RAF inhibition in BRAF-mutant melanoma cells
S Han, Y Yan, Y Ren, Y Hu, Y Wang, L Chen, Z Zhi… - Cancer Research, 2021 - AACR
The long noncoding RNA (lncRNA) SAMMSON is required for human melanoma cell growth
and survival. However, whether SAMMSON regulates the response of mutant BRAF …
and survival. However, whether SAMMSON regulates the response of mutant BRAF …
Induction of senescence in cancer cells by a novel combination of cucurbitacin B and withanone: Molecular mechanism and therapeutic potential
Cancer, an uncontrolled proliferation syndrome, is treated with synthetic chemotherapeutic
drugs that are associated with severe adverse effects. Development and application of new …
drugs that are associated with severe adverse effects. Development and application of new …
Malignant pleural mesothelioma: genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets
OD Røe, E Anderssen, H Sandeck, T Christensen… - Lung cancer, 2010 - Elsevier
Malignant pleural mesothelioma is an asbestos-related multi-resistant tumour with
increasing incidence worldwide. Well-characterized snap-frozen normal parietal, visceral …
increasing incidence worldwide. Well-characterized snap-frozen normal parietal, visceral …