Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated
cells, and to interact with its environment to maintain a balance between quiescence …

The cancer stem cell (CSC) model has been established as a cellular mechanism that
contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent …

Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional
conversion between tumor-initiating stem cells and nonstem cells triggered by an …

Biologists have long been intrigued by the possibility that cells can change their identity, a
phenomenon known as cellular plasticity. The discovery that terminally differentiated cells …

The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers
heterogeneity to some cancers beyond that explained by clonal evolution or environmental …

Current models of stem cell biology assume that normal and neoplastic stem cells reside at
the apices of hierarchies and differentiate into nonstem progeny in a unidirectional manner …

Stem-cell niches in mammalian tissues are often heterogeneous and compartmentalized;
however, whether distinct niche locations determine different stem-cell fates remains …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

In epithelial tissues, the lineage relationship between normal progenitor cells and cell type
(s) of origin for cancer has been poorly understood. Here we show that a known regulator of …

The identity and behavior of mouse spermatogenic stem cells have been a long-standing
focus of interest. In the prevailing" A s model," stem cell function is restricted to singly …