During testis development, proliferation and death of gonocytes are highly regulated to
establish a standard population of adult stem spermatogonia that maintain normal …

Stem cells have been described in most adult tissues, where they play a key role in
maintaining tissue homeostasis. As they self-renew throughout life, accumulating genetic …

The field of hematopoietic oncology has traditionally focused on the study of hematopoietic
cell autonomous genetic events in an effort to understand malignant transformation and …

Pluripotent stem cells have great clinical potential for tissue regeneration/repair in humans.
The use of embryonic stem (ES) cells is ethically controversial, leading to searches for other …

Despite numerous advances in cell biology, genetics, and developmental biology, cancer
origin has been attributed to genetic mechanisms primarily involving mutations …

Spermatogenesis is sensitive to the chemotherapeutic drug cyclophosphamide, which
decreases the patients' sperm count. Since the recovery of fertility is dependent on …

Spermatogonial stem cells (SSCs) are the germline stem cells that are essential for the
maintenance of spermatogenesis in the testis. However, it has not been sufficiently …

Cancer stem cells often have phenotypic and functional characteristics similar to normal
stem cells including the properties of self-renewal and differentiation. Recent findings …

Drosophila melanogaster has historically been a workhorse model organism for studying
developmental biology. In addition, Drosophila is an excellent model for studying how …

Both in mice and humans, two major SPO11 isoforms are generated by alternative splicing:
SPO11α (exon 2 skipped) and SPO11β. Thus, the alternative splicing event must have …