The evidence that cyclooxygenase‐2 (COX‐2) is upregulated and plays an important role in
carcinogenesis of gastric cancer has triggered the topic of COX‐2 inhibitors as …

Most pharmacists know that aspirin's origins lie with willow bark, but they may be unaware of
its role in the development of the pharmaceutical industry. Evolving from salacin (the active …

OBJECTIVES: Subjects in the Prevention of Colorectal Sporadic Adenomatous Polyps
(PreSAP) trial (PRESAP/NCT00141193/www. clinicaltrials. gov) were studied to determine …

OBJECTIVES: Non-steroidal anti-inflammatory drugs (NSAIDs) have been documented in
animal and human studies to reduce risk for colorectal cancer and adenomatous polyps, but …

A scaffold with bicyclic core carrying pyridazinone moiety, which exhibited potent in vivo anti-
inflammatory activities, was introduced in this article. The design of these compounds was …

Abstract Background: Prostaglandin-endoperoxide synthase 2 (PTGS2, the HUGO Gene
Nomenclature Committee–approved official symbol for cycloxygenase-2, COX-2) and its …

Purpose Acid suppressants are commonly prescribed medications. Laboratory studies
suggest a mechanism by which they could increase colorectal cancer (CRC) risk. A few …

Canine cancer has become more prevalent in recent years because of increased life
expectancy and greater attention to the health of pets. The range of cancers seen in dogs is …

Colitis-associated cancer (CAC) is one of clear examples of inflammation–carcinogenesis
sequence, by which the strict control of colitis with potent anti-inflammatory or antioxidative …

Together, gastrointestinal (GI) cancers now account for 25% of neoplastic deaths in the
West. In Poland, GI cancer rates are likely to increase further as westernization progresses …