PURPOSE OF REVIEW Traumatic brain injury (TBI) encompasses a group of
heterogeneous manifestations of a disease process with high neurologic morbidity and, for …

Remarkable progress made in the past few decades in brain research enables the
manipulation of neuronal activity in single neurons and neural circuits and thus allows the …

Object Cerebral ischemia is the leading cause of preventable death in cases of major
trauma with severe traumatic brain injury (TBI). Intracranial pressure (ICP) control and …

BACKGROUND: Brain hypoxia (BH) can aggravate outcome after severe traumatic brain
injury (TBI). Whether BH or reduced brain oxygen (Pbto 2) is an independent outcome …

Cortical spreading depolarization causes a breakdown of electrochemical gradients
following acute brain injury, and also elicits dynamic changes in regional cerebral blood flow …

Background and Purpose—Disturbances of cerebrovascular autoregulation are thought to
be involved in delayed cerebral ischemia and infarction after aneurysmal subarachnoid …

To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential.
Cerebral tissue oxygenation represents the balance between oxygen supply and …

Objective: To evaluate whether two newly developed indexes of brain tissue oxygen
pressure reactivity (ORx and b P ti o 2) provide information on the status of cerebrovascular …

Background and Purpose—To identify a minimally acceptable cerebral perfusion pressure
threshold above which the risks of brain tissue hypoxia (BTH) and oxidative metabolic crisis …

Objective Delayed ischemic neurological deficit (DIND) contributes to poor outcome in
subarachnoid hemorrhage (SAH) patients. Because there is continuing uncertainty as to …