PsrA is a novel regulator contributes to antibiotic synthesis, bacterial virulence, cell motility and extracellular polysaccharides production in Serratia marcescens

X Pan, M Tang, J You, T Osire, C Sun… - Nucleic Acids …, 2022 - academic.oup.com
Serratia marcescens is a Gram-negative bacterium of the Enterobacteriaceae family that can
produce numbers of biologically active secondary metabolites. However, our understanding …

Prodigiosin pigment of Serratia marcescens is associated with increased biomass production

PL Haddix, RMQ Shanks - Archives of microbiology, 2018 - Springer
Serratia marcescens is a gram-negative, facultatively-anaerobic bacterium and opportunistic
pathogen which produces the red pigment prodigiosin. We employed both batch culture and …

[HTML][HTML] Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants

J Hage-Hülsmann, A Grünberger, S Thies… - PloS one, 2018 - journals.plos.org
Bacterial secondary metabolites are naturally produced to prevail amongst competitors in a
shared habitat and thus represent a valuable source for antibiotic discovery. The …

LysR-Type Transcriptional Regulator MetR Controls Prodigiosin Production, Methionine Biosynthesis, Cell Motility, H2O2 Tolerance, Heat Tolerance, and …

X Pan, C Sun, M Tang, J You, T Osire… - Applied and …, 2020 - Am Soc Microbiol
Prodigiosin, a secondary metabolite produced by Serratia marcescens, has attracted
attention due to its immunosuppressive, antimicrobial, and anticancer properties. However …

[HTML][HTML] Identification of Essential Genes Associated With Prodigiosin Production in Serratia marcescens FZSF02

X Jia, F Liu, K Zhao, J Lin, Y Fang, S Cai, C Lin… - Frontiers in …, 2021 - frontiersin.org
Prodigiosin is a promising secondary metabolite produced mainly by Serratia strains. To
study the global regulatory mechanism of prodigiosin biosynthesis, a mutagenesis library …

[HTML][HTML] Putting on the brakes: Bacterial impediment of wound healing

KM Brothers, NA Stella, KM Hunt, EG Romanowski… - Scientific reports, 2015 - nature.com
The epithelium provides a crucial barrier to infection and its integrity requires efficient wound
healing. Bacterial cells and secretomes from a subset of tested species of bacteria inhibited …

Prodigiosin: unveiling the crimson wonder–a comprehensive journey from diverse bioactivity to synthesis and yield enhancement

Y Lu, D Liu, R Jiang, Z Li, X Gao - Frontiers in Microbiology, 2024 - frontiersin.org
Prodigiosin (PG) is a red tripyrrole pigment from the prodiginine family that has attracted
widespread attention due to its excellent biological activities, including anticancer …

[HTML][HTML] Transcriptional factor OmpR positively regulates prodigiosin biosynthesis in Serratia marcescens FZSF02 by binding with the promoter of the prodigiosin …

X Jia, K Zhao, F Liu, J Lin, C Lin, J Chen - Frontiers in Microbiology, 2022 - frontiersin.org
Prodigiosin is a promising secondary metabolite mainly produced by Serratia marcescens.
The production of prodigiosin by S. marcescens is regulated by different kinds of regulatory …

[HTML][HTML] Thermoregulation of prodigiosin biosynthesis by is controlled at the transcriptional level and requires HexS

EG Romanowski, KM Lehner, NC Martin… - Polish journal of …, 2019 - sciendo.com
Materials and Methods Bacterial strains and growth. Bacterial strains are listed in Table I.
Bacteria were grown in LB broth (Bertani 1951), supplemented with antibiotics when …

[HTML][HTML] BarA/UvrY differentially regulates prodigiosin biosynthesis and swarming motility in Serratia marcescens FS14

X Liu, D Xu, D Wu, M Xu, Y Wang, W Wang… - Research in …, 2023 - Elsevier
BarA/UvrY, a two-component system and global regulator that controls expression of more
than a hundred of genes involved in virulence, motility, biofilm formation, and central carbon …