Insight into the pivotal role of signaling pathways in psoriasis pathogenesis, potential therapeutic molecules and drug delivery approaches

Y Tomar, S Gorantla, G Singhvi - Drug discovery today, 2023 - Elsevier
Highlights•Psoriasis is a chronic inflammatory skin disorder affecting 125 million people
worldwide.•The intracellular pathways JAK-STAT, PDE4, S1P, A 3 AR and NF-κB have been …

[HTML][HTML] Benefits of topical indigo naturalis nanofibrous patch on psoriatic skin: A transdermal strategy for botanicals

P Wang, J Gao, S Guo, H Liu, C Cao, S Hong, Y Sun… - Materials Today Bio, 2023 - Elsevier
Indigo naturalis (IN) has been extensively used as a topical treatment for psoriasis.
However, clinical applications of IN in ointment were hampered by its limited transdermal …

CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17

KJ Cavagnero, F Li, T Dokoshi, T Nakatsuji… - Journal of Experimental …, 2024 - rupress.org
The skin provides an essential barrier for host defense through rapid action of multiple
resident and recruited cell types, but the complex communication network governing these …

[HTML][HTML] Elucidating the ability of CGRP to modulate microvascular events in mouse skin

AA Zarban, H Chaudhry, J de Sousa Valente… - International Journal of …, 2022 - mdpi.com
Oedema formation and polymorphonuclear leukocyte (neutrophil) accumulation are
involved in both acute and chronic inflammation. Calcitonin gene-related peptide (CGRP) is …

[HTML][HTML] Non-Invasive Assessment of Skin Surface Proteins of Psoriasis Vulgaris Patients in Response to Biological Therapy

K Orro, K Salk, A Merkulova, K Abram… - International Journal of …, 2023 - mdpi.com
Measurements of skin surface biomarkers have enormous value for the detailed assessment
of skin conditions, both for clinical application and in skin care. The main goals of the current …

Содержание субпопуляций CD4+ T-клеток в прогнозе эффективности биологической терапии псориаза у детей

ДГ Купцова, ТВ Радыгина, ОВ Курбатова… - Медицинская …, 2023 - mimmun.ru
Аннотация Псориаз—хроническое воспалительное заболевание кожи,
характеризующееся повышенной пролиферацией эпидермальных клеток, нарушением …

[HTML][HTML] β-Hydroxy-β-Methylbutyric Acid Promotes Repair of Sheep Myoblast Injury by Inhibiting IL-17/NF-ΚB Signaling

J Zheng, B Li, Y Yan, X Huang, E Zhang - International Journal of …, 2022 - mdpi.com
Delayed muscle development and impaired tissue repair are common occurrences in sheep
reared for mutton. Therefore, understanding the regulatory mechanisms involved in muscle …

A Study Correlation between Levels IL-15, IL-23 and TNF-α in a Sample of Iraqi Psoriasis Patients

SA Sabri, SR Ibraheem - Ibn AL-Haitham Journal For Pure …, 2024 - jih.uobaghdad.edu.iq
Psoriasis is defined as a series of events that begins in its initial stage with dermatitis and
then progresses to more widespread inflammation and increased oxidative stress. The aim …

Analysis of the Immunomodulatory Properties of Mycobacterium Cell Wall Fraction on the Cytokine Production of Peripheral Blood Mononuclear Cells of Healthy Dogs

R Ward - 2024 - atrium.lib.uoguelph.ca
Mycobacterium cell wall fraction (MCWF) is a Toll-like receptor agonist that is derived from
non-pathogenic Mycobacterium phlei. The objective of this research was to evaluate host …

[PDF][PDF] Materials Today Bio

Z Wang, C Sun, H Wu, J Xie, T Zhang, Y Li, X Xu… - 2022 - scienceopen.com
Pulmonary drug delivery has the advantages of being rapid, efficient, and well-targeted, with
few systemic side effects. In addition, it is non-invasive and has good patient compliance …