Integrin receptors for the extracellular matrix activate intracellular signaling pathways that
are critical for tissue development, homeostasis, and regeneration/repair, and their loss or …

Integrins are cell receptors involved in several metabolic pathways often associated with cell
proliferation. Some of these integrins are downregulated during human physical …

Background Ossification of the posterior longitudinal ligament (OPLL), an emerging
heterotopic ossification disease, causes spinal cord compression, resulting in motor and …

Simple Summary Recent advances in anticancer drug research led to the approval of new
small molecules with different mechanisms of action, therapeutic indications, and adverse …

Inflammation is associated with many pathology disorders and the malignant progression of
most cancers. Therefore, targeting inflammatory pathways could provide a promising …

Organophosphate esters (OPEs) can cause adverse biological effects through binding to
integrin α v β 3. However, few studies have focused on the binding activity and mechanism …

The integrin heterodimer is a transmembrane protein critical for driving cellular process and
is a therapeutic target in the treatment of multiple diseases linked to its malfunction …

Poor intracellular uptake of therapeutics in the tumor parenchyma is a key issue in cancer
therapy. We describe a novel approach to enhance tumor targeting and achieve targeted …

Extracellular vesicles (EVs), characterized by low immunogenicity, high biocompatibility and
targeting specificity along with excellent blood-brain barrier permeability, are increasingly …

Finding novel therapeutic modalities, improving drug delivery efficiency and targeting, and
reducing the immune escape of tumor cells are currently hot topics in the field of tumor …