The cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific
mRNA binding proteins that control translation in development, health, and disease. CPEB1 …

The late 1990s were banner years in molecular neuroscience; seminal studies
demonstrated that local protein synthesis, at or near synapses, was necessary for synaptic …

Background Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with
dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a …

Consolidation of long-term memories depends on de novo protein synthesis. Several
translational regulators have been identified, and their contribution to the formation of …

Background Hybridisation and introgression play key roles in the evolutionary history of
animal species. They are commonly observed within several orders in wild birds. The …

Neuroinflammation causes neuronal injury in multiple sclerosis (MS) and other neurological
diseases. MicroRNAs (miRNAs) are important modulators of neuronal stress responses, but …

Triggering receptor expressed on myeloid cells 2 (TREM2), a receptor exclusively
expressed by microglia in the brain, modulates microglial immune homeostasis. Human …

Background Vertebrate CPEB proteins bind mRNAs at cytoplasmic polyadenylation
elements (CPEs) in their 3′ UTRs, leading to cytoplasmic changes in their poly (A) tail …

Biomolecular condensates, membraneless organelles found throughout the cell, play critical
roles in many aspects of cellular function. Ribonucleoprotein granules (RNPs) are a type of …

Posttranscriptional gene regulation includes mRNA transport, localization, translation, and
regulation of mRNA stability. CPEB (c ytoplasmic p olyadenylation e lement b inding) family …