Steatotic liver disease: pathophysiology and emerging pharmacotherapies
M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - ASPET
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …
Consequently, the metabolic dysfunction-associated steatotic liver disease …
[HTML][HTML] Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis
Background Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a
novel direction, and the existing clinical studies have little effective evidence for its …
novel direction, and the existing clinical studies have little effective evidence for its …
[HTML][HTML] Lessons on drug development: a literature review of challenges faced in nonalcoholic fatty liver disease (NAFLD) clinical trials
JYS Chen, D Chua, CO Lim, WX Ho… - International Journal of …, 2022 - mdpi.com
NAFLD is the most common chronic liver disease worldwide, occurring in both obese and
lean patients. It can lead to life-threatening liver diseases and nonhepatic complications …
lean patients. It can lead to life-threatening liver diseases and nonhepatic complications …
[HTML][HTML] The role of phytosterols in nonalcoholic fatty liver disease
O Frasinariu, R Serban, LM Trandafir, I Miron… - Nutrients, 2022 - mdpi.com
Nonalcoholic fatty liver disease is now recognized as the most common cause of chronic
liver disease with an increasing prevalence in both adults and children. Although the …
liver disease with an increasing prevalence in both adults and children. Although the …
[HTML][HTML] Microbiota dysbiosis and gut barrier dysfunction associated with non-alcoholic fatty liver disease are modulated by a specific metabolic cofactors' combination
S Quesada-Vázquez, C Bone, S Saha… - International Journal of …, 2022 - mdpi.com
The gut is a selective barrier that not only allows the translocation of nutrients from food, but
also microbe-derived metabolites to the systemic circulation that flows through the liver …
also microbe-derived metabolites to the systemic circulation that flows through the liver …
[HTML][HTML] Multi-omics reveals inhibitory effect of baicalein on non-alcoholic fatty liver disease in mice
P Li, J Hu, H Zhao, J Feng, B Chai - Frontiers in Pharmacology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, whose
etiology is poorly understood. Accumulating evidence indicates that gut microbiota plays an …
etiology is poorly understood. Accumulating evidence indicates that gut microbiota plays an …
[HTML][HTML] Protective effects of caffeine against palmitate-induced lipid toxicity in primary rat hepatocytes is associated with modulation of adenosine receptor A1 …
JC Arroyave-Ospina, M Buist-Homan, M Schmidt… - Biomedicine & …, 2023 - Elsevier
Background Epidemiological evidence has shown an association between coffee
consumption and reduced risk for chronic liver diseases, including metabolic-dysfunction …
consumption and reduced risk for chronic liver diseases, including metabolic-dysfunction …
[HTML][HTML] Liraglutide attenuates type 2 diabetes mellitus-associated non-alcoholic fatty liver disease by activating AMPK/ACC signaling and inhibiting ferroptosis
T Guo, W Yan, X Cui, N Liu, X Wei, Y Sun, KX Fan… - Molecular …, 2023 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is one of the most common
complications of type 2 diabetes mellitus (T2DM). The pathogenesis of NAFLD involves …
complications of type 2 diabetes mellitus (T2DM). The pathogenesis of NAFLD involves …
[HTML][HTML] A new nutraceutical (Livogen Plus®) improves liver steatosis in adults with non-alcoholic fatty liver disease
Background Currently, there is no approved medication for non-alcoholic fatty liver disease
management. Pre-clinical and clinical studies showed that several bioactive molecules in …
management. Pre-clinical and clinical studies showed that several bioactive molecules in …
[HTML][HTML] The effect of DASH diet on glycemic response, meta-inflammation and serum LPS in obese patients with NAFLD: a double-blind controlled randomized …
F Rooholahzadegan, S Arefhosseini, H Tutunchi… - Nutrition & …, 2023 - Springer
Background As dietary approaches to stop hypertension (DASH) dietary pattern has been
shown to be effective in hypertension and obesity, the present study investigated the effects …
shown to be effective in hypertension and obesity, the present study investigated the effects …