NLR receptors in plant immunity: making sense of the alphabet soup

MP Contreras, D Lüdke, H Pai, AA Toghani… - EMBO …, 2023 - embopress.org
Plants coordinately use cell‐surface and intracellular immune receptors to perceive
pathogens and mount an immune response. Intracellular events of pathogen recognition are …

[HTML][HTML] R we there yet? Advances in cloning resistance genes for engineering immunity in crop plants

R Chen, K Gajendiran, BBH Wulff - Current opinion in plant biology, 2024 - Elsevier
Over the past three decades, significant progress has been made in the field of resistance
(R) gene cloning. Advances in recombinant DNA technology, genome sequencing …

NLR immune receptor–nanobody fusions confer plant disease resistance

J Kourelis, C Marchal, A Posbeyikian, A Harant… - Science, 2023 - science.org
Plant pathogens cause recurrent epidemics, threatening crop yield and global food security.
Efforts to retool the plant immune system have been limited to modifying natural components …

Pathogen perception and signaling in plant immunity

PN Dodds, J Chen, MA Outram - The Plant Cell, 2024 - academic.oup.com
Plant diseases are a constant and serious threat to agriculture and ecological biodiversity.
Plants possess a sophisticated innate immunity system capable of detecting and responding …

New biochemical principles for NLR immunity in plants

J Chai, W Song, JE Parker - Molecular Plant-Microbe …, 2023 - Am Phytopath Society
While working for the United States Department of Agriculture on the North Dakota
Agricultural College campus in Fargo, North Dakota, in the 1940s and 1950s, Harold H. Flor …

A blast fungus zinc-finger fold effector binds to a hydrophobic pocket in host Exo70 proteins to modulate immune recognition in rice

JC De la Concepcion, K Fujisaki… - Proceedings of the …, 2022 - National Acad Sciences
Exocytosis plays an important role in plant–microbe interactions, in both pathogenesis and
symbiosis. Exo70 proteins are integral components of the exocyst, an octameric complex …

[HTML][HTML] Pathways to engineering plant intracellular NLR immune receptors

R Zdrzałek, C Stone, JC De la Concepcion… - Current Opinion in Plant …, 2023 - Elsevier
Factors including climate change and increased global exchange are set to escalate the
prevalence of plant diseases, posing an unprecedented threat to global food security and …

Emerging principles in the design of bioengineered made-to-order plant immune receptors

C Marchal, H Pai, S Kamoun, J Kourelis - Current Opinion in Plant Biology, 2022 - Elsevier
Crop yield and global food security are under constant threat from plant pathogens with the
potential to cause epidemics. Traditional breeding for disease resistance can be too slow to …

Bioengineering a plant NLR immune receptor with a robust binding interface toward a conserved fungal pathogen effector

R Zdrzałek, Y Xi, T Langner, AR Bentham… - Proceedings of the …, 2024 - pnas.org
Bioengineering of plant immune receptors has emerged as a key strategy for generating
novel disease resistance traits to counteract the expanding threat of plant pathogens to …

Molecular engineering of plant immune receptors for tailored crop disease resistance

L Cadiou, F Brunisholz, S Cesari, T Kroj - Current Opinion in Plant Biology, 2023 - Elsevier
The specific recognition of pathogen effectors by intracellular nucleotide-binding and
leucine-rich repeat domain receptors (NLRs) is an important component of plant immunity …