Colchicine, a natural and ancient drug still used today, is traditionally considered the staple
therapy for gout and a second-line treatment for pericarditis, as well as a basic part of …

Human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have great potential
application in almost all areas of cardiovascular research. A current major goal of the field is …

Although atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia, the
basic mechanisms underlying this disorder remain incompletely understood. During the past …

Atrial fibrillation (AF) is the most frequently encountered clinical arrhythmia and is associated
with increased morbidity and mortality. Ectopic activity and reentry are considered major …

Rhythm and rate strategies are considered equivalent for the management of atrial
fibrillation (AF). Moreover, both strategies are intended for improving symptoms and quality …

Mutations in SCN5A, encoding the cardiac sodium channel, are linked with familial atrial
fibrillation (AF) but the underlying pathophysiologic mechanisms and implications for …

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial
arrhythmogenic syndrome characterized by sudden death. There are several genetic forms …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and has a significant impact on
morbidity and mortality. Current antiarrhythmic drugs for AF suffer from limited safety and …

An increased burden of premature atrial contractions (PACs) has long been considered a
benign phenomenon. However, strong evidence of their involvement in the occurrence of …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, but our knowledge of the
arrhythmogenic substrate is incomplete. Alternans, the beat-to-beat alternation in the shape …