Targeting human Hippo TEAD binding interface with YAP/TAZ-derived, flexibility-reduced peptides in gastric cancer
D Wu, L Luo, Z Yang, Y Chen, Y Quan, Z Min - International Journal of …, 2021 - Springer
Human Hippo signaling pathway plays an important role in the tumorigenesis of diverse
cancers and has been recognized as an attractive therapeutic target of gastric cancer. The …
cancers and has been recognized as an attractive therapeutic target of gastric cancer. The …
Directed molecular engineering of Mig6 peptide selectivity between proto-oncogene ErbB family receptor tyrosine kinases
Z Qiao, S Wang - Biotechnology and Bioprocess Engineering, 2021 - Springer
The ErbB signaling pathway plays important roles in normal physiology and cancer, which
consists of four proto-oncogene receptor tyrosine kinases ErbB1/EGFR ErbB2/Her2 …
consists of four proto-oncogene receptor tyrosine kinases ErbB1/EGFR ErbB2/Her2 …
Systematic identification of the druggable interactions between human protein kinases and naturally occurring compounds in endometriosis
L Jiang, C Tang, J Rao, Q Xue, H Wu, D Wu… - … Biology and Chemistry, 2017 - Elsevier
Diverse kinase signaling pathways have been involved in the pathogenesis of
endometriosis (EM), which can be modulated either by directly targeting the hub kinases or …
endometriosis (EM), which can be modulated either by directly targeting the hub kinases or …
Revisiting the molecular mechanism of acquired resistance to reversible tyrosine kinase inhibitors caused by EGFR gatekeeper T790M mutation in non-small-cell lung …
Y Zhao, Y Jiao, F Sun, X Liu - Medicinal Chemistry Research, 2018 - Springer
Background A variety of tyrosine kinase inhibitors (TKIs) have been developed to target
human epidermalgrowth factor receptor (EGFR) for non-small-cell lung cancer (NSCLC) …
human epidermalgrowth factor receptor (EGFR) for non-small-cell lung cancer (NSCLC) …
Computational Analysis and Rational Design of N-Substituting Perturbation on the Affinity and Specificity of Pediatric Fyn SH3-Peptoid Interaction
Q Liu, J Wang, L Shi, X Shao - Journal of Computational …, 2023 - ui.adsabs.harvard.edu
Human nonreceptor tyrosine kinase (TK) Fyn is implicated in various cellular processes and
has been exploited as a sophisticated druggable target of pediatric T-cell lymphoma by …
has been exploited as a sophisticated druggable target of pediatric T-cell lymphoma by …
[HTML][HTML] Computational design of antiangiogenic peptibody by fusing human IgG1 Fc fragment and HRH peptide: structural modeling, energetic analysis, and …
Peptibodies represent a new class of biological therapeutics with combination of peptide
activity and antibody-like properties. Previously, we discovered a novel peptide HRH that …
activity and antibody-like properties. Previously, we discovered a novel peptide HRH that …
Rational optimization of tumor suppressor‐derived peptide inhibitor selectivity between oncogene tyrosine kinases ErbB1 and ErbB2
Y Deng, J Li - Archiv der Pharmazie, 2017 - Wiley Online Library
The tumor‐suppressor protein Mig‐6 has been found to directly target and inhibit the human
ErbB receptor tyrosine kinases ErbB1 and ErbB2. Despite their highly homologous nature …
ErbB receptor tyrosine kinases ErbB1 and ErbB2. Despite their highly homologous nature …
Peptide selectivity between the PDZ domains of human pregnancy‐related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen …
ML Sun, LM Sun, YQ Wang - Journal of Molecular Recognition, 2018 - Wiley Online Library
The human HtrA family of serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) are the key
enzymes associated with pregnancy and closely related to the development and …
enzymes associated with pregnancy and closely related to the development and …
Rational truncation, mutation, and halogenation of bradykinin neuropeptides as potent ACEII inhibitors by integrating molecular dynamics simulations, quantum …
J Fu, S Chen, Z Ni - Journal of the Chinese Chemical Society, 2022 - Wiley Online Library
Human angiotensin‐converting enzyme‐ii (ACEII) is involved in the brain renin‐angiotensin
system and plays a key role in angiotensin metabolism and neural regulation. Here, we …
system and plays a key role in angiotensin metabolism and neural regulation. Here, we …
Systematic response of staurosporine scaffold‐based inhibitors to drug‐resistant cancer kinase mutations
Y He - Archiv der Pharmazie, 2020 - Wiley Online Library
Human protein kinases have been established as promising druggable targets in cancer
therapy. However, a large number of acquired drug‐resistant kinase mutations are observed …
therapy. However, a large number of acquired drug‐resistant kinase mutations are observed …