The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …

Heart failure is a major cause of death and disability. Impairments in blood circulation that
accompany heart failure can be traced, in part, to alterations in the activity of the …

Summary Background Sarcoplasmic/endoplasmic reticulum Ca 2+-ATPase (SERCA2a)
activity is deficient in the failing heart. Correction of this abnormality by gene transfer might …

Background—Adeno-associated virus type 1/sarcoplasmic reticulum Ca2+-ATPase was
assessed in a randomized, double-blind, placebo-controlled, phase 2 study in patients with …

Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …

Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …

This review addresses open questions about the role of β-adrenergic receptors in cardiac
function and failure. Cardiomyocytes express all three β-adrenergic receptor subtypes—β1 …

Rationale: The Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In
Cardiac Disease (CUPID 1) study was a phase 1/phase 2 first-in-human clinical gene …

Heart failure (HF) is a syndrome resulting from the inability of the cardiac pump to meet the
energy requirements of the body. Despite intensive work, the pathogenesis of the cardiac …