Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC)
with a poor prognosis. Current treatment options are limited to surgery, adjuvant …

Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …

The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular
component), and cellular components include cancer cells and non-malignant cells such as …

Receptor tyrosine kinases (RTKs) are key regulatory signaling proteins governing cancer
cell growth and metastasis. During the last two decades, several molecules targeting RTKs …

Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) …

Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …

The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

Toripalimab (Tuoyi™) is a selective, recombinant, humanized monoclonal antibody against
programmed death protein 1 (PD-1) developed by Shanghai Junshi Bioscience Co., Ltd …

Chronic diseases (CDs) are noncommunicable illnesses with long-term symptoms
accounting for~ 70% of all deaths worldwide. For the diagnosis and prognosis of CDs …

Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment
and promotes cancer progression and resistance to therapy. Many studies reported the …