Molecular transducers of physical activity consortium (MoTrPAC): mapping the dynamic responses to exercise
Exercise provides a robust physiological stimulus that evokes cross-talk among multiple
tissues that when repeated regularly (ie, training) improves physiological capacity, benefits …
tissues that when repeated regularly (ie, training) improves physiological capacity, benefits …
Pleiotropy in complex traits: challenges and strategies
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
Regulatory genomic circuitry of human disease loci by integrative epigenomics
Annotating the molecular basis of human disease remains an unsolved challenge, as 93%
of disease loci are non-coding and gene-regulatory annotations are highly incomplete …
of disease loci are non-coding and gene-regulatory annotations are highly incomplete …
Integrating predicted transcriptome from multiple tissues improves association detection
Integration of genome-wide association studies (GWAS) and expression quantitative trait
loci (eQTL) studies is needed to improve our understanding of the biological mechanisms …
loci (eQTL) studies is needed to improve our understanding of the biological mechanisms …
Genetic architectures of psychiatric disorders: the emerging picture and its implications
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …
years, there has been unprecedented progress on the genetics of many of these conditions …
GAPIT version 2: an enhanced integrated tool for genomic association and prediction
Most human diseases and agriculturally important traits are complex. Dissecting their
genetic architecture requires continued development of innovative and powerful statistical …
genetic architecture requires continued development of innovative and powerful statistical …
Meta-analysis methods for genome-wide association studies and beyond
E Evangelou, JPA Ioannidis - Nature Reviews Genetics, 2013 - nature.com
Meta-analysis of genome-wide association studies (GWASs) has become a popular method
for discovering genetic risk variants. Here, we overview both widely applied and newer …
for discovering genetic risk variants. Here, we overview both widely applied and newer …
Interpreting noncoding genetic variation in complex traits and human disease
Association studies provide genome-wide information about the genetic basis of complex
disease, but medical research has focused primarily on protein-coding variants, owing to the …
disease, but medical research has focused primarily on protein-coding variants, owing to the …
Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies
Meta-analysis is an increasingly popular tool for combining multiple different genome-wide
association studies (GWASs) in a single aggregate analysis in order to identify associations …
association studies (GWASs) in a single aggregate analysis in order to identify associations …
Analysing biological pathways in genome-wide association studies
Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …