Antiepileptic drugs alter endogenous retinoid concentrations: a possible mechanism of teratogenesis of anticonvulsant therapy
H Nau, G Tzimas, M Mondry, C Plum, HL Spohr - Life sciences, 1995 - Elsevier
The major antiepileptic drugs used for the control of seizures can induce developmental
toxicity when administered during pregnancy. Vitamin A and retinoids are thought to control …
toxicity when administered during pregnancy. Vitamin A and retinoids are thought to control …
Retinoic acid directs cardiac laterality and the expression of early markers of precardiac asymmetry
SM Smith, ED Dickman, RP Thompson, AR Sinning… - Developmental …, 1997 - Elsevier
Formation of the left/right body axis is a critical early step in embryogenesis. The heart loop
is one of the first clearly recognizable morphological asymmetries, and the molecular …
is one of the first clearly recognizable morphological asymmetries, and the molecular …
In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer
A Morrison, MC Moroni, L Ariza-McNaughton… - …, 1996 - journals.biologists.com
Expression of vertebrate Hox genes is regulated by retinoids in cell culture and in early
embryonic development. We have identified a 185-bp retinoid-responsive transcriptional …
embryonic development. We have identified a 185-bp retinoid-responsive transcriptional …
Involvement of thyroid hormone and its α receptor in avian neurulation
F Flamant, J Samarut - Developmental Biology, 1998 - Elsevier
We have analyzed the expression pattern of c-erbAα and c-erbAβ which encode the thyroid
hormone receptors (T3Rα and T3Rβ) during early chicken embryogenesis. Only c-erbAα …
hormone receptors (T3Rα and T3Rβ) during early chicken embryogenesis. Only c-erbAα …
Induction and axial patterning of the neural plate: planar and vertical signals
AR Altaba - Journal of neurobiology, 1993 - Wiley Online Library
In this review I summarize recent findings on the contributions of different cell groups to the
formation of the basic plan of the nervous system of vertebrate embryos. Midline cells of the …
formation of the basic plan of the nervous system of vertebrate embryos. Midline cells of the …
Pattern of retinoid‐induced teratogenic effects: Possible relationship with relative selectivity for nuclear retinoid receptors RARα, RARβ, and RARγ
MMA Elmazar, U Reichert, B Shroot, H Nau - Teratology, 1996 - Wiley Online Library
Retinoic acid, an oxidative metabolite of vitamin A, is involved in the control of many
biological processes including embryonic development. Excess as well as deficiency of …
biological processes including embryonic development. Excess as well as deficiency of …
Retinoic acid is required for normal morphogenetic movements during gastrulation
Retinoic acid (RA) is a central regulatory signal that controls numerous developmental
processes in vertebrate embryos. Although activation of Hox expression is considered one …
processes in vertebrate embryos. Although activation of Hox expression is considered one …
Regulation of the human HOXD4 gene by retinoids
Hox genes are developmentally regulated in mammalian embryogenetics, according to
temporally and spatially restricted patterns which are affected by retinoids, vitamin A …
temporally and spatially restricted patterns which are affected by retinoids, vitamin A …
Microfluidic systems: A new toolbox for pluripotent stem cells
SC Lesher‐Perez, JP Frampton… - Biotechnology …, 2013 - Wiley Online Library
Conventional culture systems are often limited in their ability to regulate the growth and
differentiation of pluripotent stem cells. Microfluidic systems can overcome some of these …
differentiation of pluripotent stem cells. Microfluidic systems can overcome some of these …
Effects of retinoic acid on the expression of retinoic acid receptors during zebrafish embryogenesis
J Joore, GBLJ van der Lans, PH Lanser… - Mechanisms of …, 1994 - Elsevier
The cDNAs encoding the zebrafish homologs of retinoic acid receptor α (zRARα) and γ
(zRARγ) were isolated and their expression studied in normal and retinoic acid (RA) treated …
(zRARγ) were isolated and their expression studied in normal and retinoic acid (RA) treated …