Microscopy methods to visualize nuclear organization in biomechanical studies
HHS Kim, M Lakadamyali - Current Opinion in Biomedical Engineering, 2024 - Elsevier
The mechanical environment plays an important role in influencing cell identity. The
nucleus's organization and mechanical state are essential regulators of cellular function …
nucleus's organization and mechanical state are essential regulators of cellular function …
Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope
M Wallace, H Zahr, S Perati, CD Morsink… - Molecular biology of …, 2023 - Am Soc Cell Biol
The LMNA gene encodes the nuclear envelope proteins Lamins A and C, which comprise a
major part of the nuclear lamina, provide mechanical support to the nucleus, and participate …
major part of the nuclear lamina, provide mechanical support to the nucleus, and participate …
Microtubule forces drive nuclear damage in LMNA cardiomyopathy
DA Pavlov, CS Corredera, M Dehghany, J Heffler… - bioRxiv, 2024 - biorxiv.org
Nuclear homeostasis requires a balance of forces between the cytoskeleton and nucleus.
Variants in LMNA disrupt this balance by weakening the nuclear lamina, resulting in nuclear …
Variants in LMNA disrupt this balance by weakening the nuclear lamina, resulting in nuclear …
Impaired lamin localization to the nuclear envelope is responsible for nuclear damage in LMNA mutant iPSC-derived cardiomyocytes
M Wallace, H Zahr, S Perati, CD Morsink, LE Johnson… - bioRxiv, 2021 - biorxiv.org
The LMNA gene encodes the nuclear envelope proteins Lamins A and C, which comprise a
major part of the nuclear lamina, provide mechanical support to the nucleus, and participate …
major part of the nuclear lamina, provide mechanical support to the nucleus, and participate …