Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …

Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal
inflammation of unknown cause encompassing Crohn's disease (CD) and ulcerative colitis …

Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of
patients. Here, we applied single-cell technologies to iCD lesions to address whether …

The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial.
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …

Inflammatory bowel disease (IBD) is one relapsing and lifelong disease that affects millions
of patients worldwide. Increasing evidence has recently highlighted immune-system …

A previously unappreciated cell type of the innate immune system, termed innate lymphoid
cells (ILCs), has been characterized in mice and humans and found to influence the …

Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine that presents
clinically with abdominal pain, mucopurulent stools, and posterior urgency. The lesions of …

Inflammatory bowel disease (IBD) is considered a chronic inflammatory and multifactorial
disease of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two …

Mounting evidence has shown that an alteration of the gut microbiota is associated with diet,
and plays an important role in animal health and metabolic diseases. However, little is …

IBD treatment is undergoing a transformation with an expanding repertoire of drugs targeting
different aspects of the immune response. Three novel classes of drugs have emerged in the …