IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
[HTML][HTML] Innate lymphoid cells in intestinal homeostasis and inflammatory bowel disease
A Saez, R Gomez-Bris, B Herrero-Fernandez… - International journal of …, 2021 - mdpi.com
Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal
inflammation of unknown cause encompassing Crohn's disease (CD) and ulcerative colitis …
inflammation of unknown cause encompassing Crohn's disease (CD) and ulcerative colitis …
[HTML][HTML] Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of
patients. Here, we applied single-cell technologies to iCD lesions to address whether …
patients. Here, we applied single-cell technologies to iCD lesions to address whether …
[HTML][HTML] Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy
P Pavlidis, A Tsakmaki, E Pantazi, K Li… - Nature …, 2022 - nature.com
The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial.
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …
[HTML][HTML] Toll-like receptors and inflammatory bowel disease
Y Lu, X Li, S Liu, Y Zhang, D Zhang - Frontiers in immunology, 2018 - frontiersin.org
Inflammatory bowel disease (IBD) is one relapsing and lifelong disease that affects millions
of patients worldwide. Increasing evidence has recently highlighted immune-system …
of patients worldwide. Increasing evidence has recently highlighted immune-system …
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
GF Sonnenberg, D Artis - Nature medicine, 2015 - nature.com
A previously unappreciated cell type of the innate immune system, termed innate lymphoid
cells (ILCs), has been characterized in mice and humans and found to influence the …
cells (ILCs), has been characterized in mice and humans and found to influence the …
[HTML][HTML] The role and mechanism of flavonoid herbal natural products in ulcerative colitis
JC Xue, S Yuan, H Meng, XT Hou, J Li… - Biomedicine & …, 2023 - Elsevier
Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine that presents
clinically with abdominal pain, mucopurulent stools, and posterior urgency. The lesions of …
clinically with abdominal pain, mucopurulent stools, and posterior urgency. The lesions of …
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome
A Shahini, A Shahini - Journal of Cell Communication and Signaling, 2023 - Springer
Inflammatory bowel disease (IBD) is considered a chronic inflammatory and multifactorial
disease of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two …
disease of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two …
Bisphenol A alters gut microbiome: comparative metagenomics analysis
Mounting evidence has shown that an alteration of the gut microbiota is associated with diet,
and plays an important role in animal health and metabolic diseases. However, little is …
and plays an important role in animal health and metabolic diseases. However, little is …
Interrogating host immunity to predict treatment response in inflammatory bowel disease
JL Digby-Bell, R Atreya, G Monteleone… - Nature reviews …, 2020 - nature.com
IBD treatment is undergoing a transformation with an expanding repertoire of drugs targeting
different aspects of the immune response. Three novel classes of drugs have emerged in the …
different aspects of the immune response. Three novel classes of drugs have emerged in the …