A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …

Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

Background: Observations in animal models suggest that A2A antagonists confer benefit by
modulating dopaminergic effects on the striatal dysfunction associated with motor disability …

Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also
facilitates synaptic transmission, but it is unclear if this facilitation results from pre-and/or …

This review summarizes recent developments that have contributed to understand how
adenosine receptors, particularly A2A receptors, modulate brain injury in various animal …

In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …

During brain injury, extracellular adenosine and glutamate levels increase rapidly and
dramatically. We hypothesized that local glutamate levels in the brain dictates the adenosine …

Neuronal communication plays an essential role in the propagation of information in the
brain and requires a precisely orchestrated connectivity between neurons. Synaptic …

Adenosine A2A receptors, abundantly expressed on striatal medium spiny neurons, appear
to activate signaling cascades implicated in the regulation of coexpressed ionotropic …

Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as
occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several …