[HTML][HTML] Modeling Alzheimer's disease with iPSC-derived brain cells

J Penney, WT Ralvenius, LH Tsai - Molecular psychiatry, 2020 - nature.com
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …

Current and future treatments for Alzheimer's disease

KG Yiannopoulou… - Therapeutic advances in …, 2013 - journals.sagepub.com
Alzheimer's dementia (AD) is increasingly being recognized as one of the most important
medical and social problems in older people in industrialized and non-industrialized …

Increasing value and reducing waste in research design, conduct, and analysis

JPA Ioannidis, S Greenland, MA Hlatky, MJ Khoury… - The Lancet, 2014 - thelancet.com
Correctable weaknesses in the design, conduct, and analysis of biomedical and public
health research studies can produce misleading results and waste valuable resources …

Screening for cognitive impairment in older adults: a systematic review for the US Preventive Services Task Force

JS Lin, E O'Connor, RC Rossom… - Annals of internal …, 2013 - acpjournals.org
This article has been corrected. The original version (PDF) is appended to this article as a
supplement. Background: Earlier identification of cognitive impairment may reduce patient …

Dementia in Down's syndrome

C Ballard, W Mobley, J Hardy, G Williams… - The Lancet …, 2016 - thelancet.com
Down's syndrome is the most common genetic cause of learning difficulties, and individuals
with this condition represent the largest group of people with dementia under the age of 50 …

Omega‐3 fatty acids for the treatment of dementia

M Burckhardt, M Herke, T Wustmann… - Cochrane Database …, 2016 - cochranelibrary.com
Background Omega‐3 polyunsaturated fatty acids (omega‐3 PUFAs) from fish and plant
sources are commonly considered as a promising non‐medical alternative to improve brain …

Inflammation and Alzheimer's disease

YJ Lee, SB Han, SY Nam, KW Oh, JT Hong - Archives of pharmacal …, 2010 - Springer
Alzheimer's disease (AD) is the most common form of dementia. It is characterized by
extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is …

Machine learning-based virtual screening and its applications to Alzheimer's drug discovery: a review

KA Carpenter, X Huang - Current pharmaceutical design, 2018 - ingentaconnect.com
Background: Virtual Screening (VS) has emerged as an important tool in the drug
development process, as it conducts efficient in silico searches over millions of compounds …

[HTML][HTML] Drugs for Alzheimer's disease: are they effective?

DA Casey, D Antimisiaris, J O'Brien - Pharmacy and Therapeutics, 2010 - ncbi.nlm.nih.gov
Alzheimer's disease (AD), a devastating neurodegenerative disorder, is the leading cause of
dementia in the US and in other developed countries. Patients experience progressive …

Adverse drug reactions of acetylcholinesterase inhibitors in older people living with dementia: a comprehensive literature review

S Ruangritchankul, P Chantharit… - … and clinical risk …, 2021 - Taylor & Francis
The rising of global geriatric population has contributed to increased prevalence of
dementia. Dementia is a neurodegenerative disease, which is characterized by progressive …