The rules for the conserved reaction of αβ T cell receptors (TCRs) with major
histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably …

T cell receptors (TCRs) recognize peptides presented by MHC molecules (pMHC) on an
antigen-presenting cell (APC) to discriminate foreign from self-antigens and initiate adaptive …

T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …

Adaptive immunity depends on specific recognition by a T-cell receptor (TCR) of an
antigenic peptide bound to a major histocompatibility complex (pMHC) molecule on an …

Tumor treatment is still complicated in the field of medicine. Tumor immunotherapy has been
the most interesting research field in cancer therapy. Application of chimeric antigen …

To test whether highly crossreactive αβ T cell receptors (TCRs) produced during limited
negative selection best illustrate evolutionarily conserved interactions between TCR and …

T cell–mediated heterologous immunity to different pathogens is promising for the
development of immunotherapeutic strategies. Aspergillus fumigatus and Candida albicans …

T-lymphocytes play a central role in the effector and regulatory mechanisms of the adaptive
immune response. Upon exiting the thymus they begin to undergo a series of phenotypic …

Cell-mediated cytotoxicity is one of the major mechanisms by which vertebrates control
intracellular pathogens. Two cell types are the main players in this immune response …

Decreased immune responsiveness associated with aging is generally termed
“immunosenescence”. Several theories have been proposed to explain age-related declines …