Phelan-McDermid syndrome (PMS) is caused by haploinsufficiency of the SHANK3 gene on
chromosome 22q13. 33 and is characterized by intellectual disability, hypotonia, severe …

Down syndrome (DS) is the most common aneuploidy of chromosome 21, characterized by
the presence of an extra copy of that chromosome (trisomy 21). Children with DS present …

Overexpression of the amyloid precursor protein (APP) gene on chromosome 21 in Down
syndrome (DS) has been linked to increased brain amyloid levels and early-onset …

Increasingly individuals with intellectual and developmental disabilities, including Down
syndrome, are being targeted for clinical trials. However, a challenge exists in effectively …

Those with Down syndrome (DS)—trisomy for chromosome 21—are routinely impacted by
cognitive dysfunction and behavioral challenges in children and adults and Alzheimer's …

Abstract Background Phelan-McDermid syndrome (PMS) is a genetic condition
characterized by intellectual disability, speech and language deficits, hypotonia, autism …

A proportion of young people with Down syndrome (DS) experience unexplained regression
that severely impacts on their daily lives. While this condition has been recognised by …

Abstract Background The Down syndrome population has been disproportionately affected
by Coronavirus 2019 (COVID-19) in terms of experiencing severe illness and death. Societal …

The post-discharge period is an extremely vulnerable period for patients, particularly for
those discharged from inpatient children and adolescent mental health services (CAMHS) …

Objective Mental health disorders are prevalent among individuals with intellectual
disabilities (ID). However, there is a lack of research on the impact of concomitant autism …