Progression of the PI3K/Akt signaling pathway in chronic obstructive pulmonary disease
Y Liu, H Kong, H Cai, G Chen, H Chen… - Frontiers in …, 2023 - frontiersin.org
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease
characterized by a slow progression and caused by the inhalation of harmful particulate …
characterized by a slow progression and caused by the inhalation of harmful particulate …
LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis
Y Wang, Z Ping, H Gao, Z Liu, Q Xv, X Jiang, W Yu - Autophagy, 2024 - Taylor & Francis
Renal fibrosis is a typical pathological change in chronic kidney disease (CKD). Epithelial-
mesenchymal transition (EMT) is the predominant stage. Activation of macroautophagy …
mesenchymal transition (EMT) is the predominant stage. Activation of macroautophagy …
PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson's disease in rats
HA Farid, RH Sayed, MES El-Shamarka… - …, 2023 - Springer
Parkinson's disease (PD) is the second most common progressive age-related
neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT …
neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT …
An updated patent review of AKT inhibitors (2020–present)
L Li, Y Guo, Y Lu, Y Xu, Y Lu, X Zhu… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Protein kinase B (Akt), an essential protein in the PI3K/Akt/mTOR
signaling pathway, plays a crucial role in tumor progression. Over the past two years …
signaling pathway, plays a crucial role in tumor progression. Over the past two years …
Effects of Tiliroside and Lisuride Co-Treatment on the PI3K/Akt Signal Pathway: Modulating Neuroinflammation and Apoptosis in Parkinson's Disease
Researchers are actively exploring potential bioactive compounds to enhance the
effectiveness of Lisuride (Lis) in treating Parkinson's disease (PD) over the long term, aiming …
effectiveness of Lisuride (Lis) in treating Parkinson's disease (PD) over the long term, aiming …
LncRNA TSIX aggravates spinal cord injury by regulating the PI3K/AKT pathway via the miR‐532‐3p/DDOST axis
J Dong, Z Wei, Z Zhu - Journal of Biochemical and Molecular …, 2023 - Wiley Online Library
Abstract Long noncoding RNA (lncRNA)‐X‐inactive‐specific transcript (TSIX) expression is
upregulated in spinal cord tissues following spinal cord injury (SCI). However, the role of …
upregulated in spinal cord tissues following spinal cord injury (SCI). However, the role of …
Metabolomic analysis of the Puerarin hypoglycemic activity via AMPK-mTOR and PPARγ-NF-κB signaling pathways
P Gong, J Wang, S Wang, W Yang, W Yao, N Li… - Phytomedicine, 2024 - Elsevier
Background Diabetes mellitus (DM) is a chronic metabolic disease characterized by
hyperglycemia, and its increasing prevalence is a global concern. Early diagnostic markers …
hyperglycemia, and its increasing prevalence is a global concern. Early diagnostic markers …
Elucidating the mechanism of Hongjinshen decoction in the treatment of pulmonary fibrosis based on network pharmacology and molecular docking
H Chen, Y Lin, L Zeng, S Liu - Medicine, 2022 - journals.lww.com
Background: To explore the mechanism of compound Hongginshen decoction in improving
pulmonary fibrosis based on network pharmacology. Methods: The active components and …
pulmonary fibrosis based on network pharmacology. Methods: The active components and …
Development of a Non-Target Screening and Quantitative Analysis Strategy Based on UPLC-Q-TOF/MS and UPLC-QQQ/MS to Improve the Quality Control of Wuling …
XF Huang, Y Xue, J Liang, L Yong - Molecules, 2024 - mdpi.com
Herbal medicine has been widely valued because of its remarkable efficacy and minimal
side effects. The quantitative analysis of herbal medicines is essential to ensure their safety …
side effects. The quantitative analysis of herbal medicines is essential to ensure their safety …
PCDH7 as the key gene related to the co-occurrence of sarcopenia and osteoporosis
M Liu, Y Wang, W Shi, C Yang, Q Wang, J Chen… - Frontiers in …, 2023 - frontiersin.org
Sarcopenia and osteoporosis, two degenerative diseases in older patients, have become
severe health problems in aging societies. Muscles and bones, the most important …
severe health problems in aging societies. Muscles and bones, the most important …