Progression of the PI3K/Akt signaling pathway in chronic obstructive pulmonary disease

Y Liu, H Kong, H Cai, G Chen, H Chen… - Frontiers in …, 2023 - frontiersin.org
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease
characterized by a slow progression and caused by the inhalation of harmful particulate …

LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis

Y Wang, Z Ping, H Gao, Z Liu, Q Xv, X Jiang, W Yu - Autophagy, 2024 - Taylor & Francis
Renal fibrosis is a typical pathological change in chronic kidney disease (CKD). Epithelial-
mesenchymal transition (EMT) is the predominant stage. Activation of macroautophagy …

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson's disease in rats

HA Farid, RH Sayed, MES El-Shamarka… - …, 2023 - Springer
Parkinson's disease (PD) is the second most common progressive age-related
neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT …

An updated patent review of AKT inhibitors (2020–present)

L Li, Y Guo, Y Lu, Y Xu, Y Lu, X Zhu… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Protein kinase B (Akt), an essential protein in the PI3K/Akt/mTOR
signaling pathway, plays a crucial role in tumor progression. Over the past two years …

Effects of Tiliroside and Lisuride Co-Treatment on the PI3K/Akt Signal Pathway: Modulating Neuroinflammation and Apoptosis in Parkinson's Disease

FK Alkholifi, S Devi, MF Aldawsari, AI Foudah… - Biomedicines, 2023 - mdpi.com
Researchers are actively exploring potential bioactive compounds to enhance the
effectiveness of Lisuride (Lis) in treating Parkinson's disease (PD) over the long term, aiming …

LncRNA TSIX aggravates spinal cord injury by regulating the PI3K/AKT pathway via the miR‐532‐3p/DDOST axis

J Dong, Z Wei, Z Zhu - Journal of Biochemical and Molecular …, 2023 - Wiley Online Library
Abstract Long noncoding RNA (lncRNA)‐X‐inactive‐specific transcript (TSIX) expression is
upregulated in spinal cord tissues following spinal cord injury (SCI). However, the role of …

Metabolomic analysis of the Puerarin hypoglycemic activity via AMPK-mTOR and PPARγ-NF-κB signaling pathways

P Gong, J Wang, S Wang, W Yang, W Yao, N Li… - Phytomedicine, 2024 - Elsevier
Background Diabetes mellitus (DM) is a chronic metabolic disease characterized by
hyperglycemia, and its increasing prevalence is a global concern. Early diagnostic markers …

Elucidating the mechanism of Hongjinshen decoction in the treatment of pulmonary fibrosis based on network pharmacology and molecular docking

H Chen, Y Lin, L Zeng, S Liu - Medicine, 2022 - journals.lww.com
Background: To explore the mechanism of compound Hongginshen decoction in improving
pulmonary fibrosis based on network pharmacology. Methods: The active components and …

Development of a Non-Target Screening and Quantitative Analysis Strategy Based on UPLC-Q-TOF/MS and UPLC-QQQ/MS to Improve the Quality Control of Wuling …

XF Huang, Y Xue, J Liang, L Yong - Molecules, 2024 - mdpi.com
Herbal medicine has been widely valued because of its remarkable efficacy and minimal
side effects. The quantitative analysis of herbal medicines is essential to ensure their safety …

PCDH7 as the key gene related to the co-occurrence of sarcopenia and osteoporosis

M Liu, Y Wang, W Shi, C Yang, Q Wang, J Chen… - Frontiers in …, 2023 - frontiersin.org
Sarcopenia and osteoporosis, two degenerative diseases in older patients, have become
severe health problems in aging societies. Muscles and bones, the most important …