Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's
disease (PD) are a heterogeneous group of disorders characterized by progressive …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

In spite of the increasing number of biologics license applications, the development of
covalent inhibitors is still a growing field within drug discovery. The successful approval of …

The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed
since its birth in 2001, attracting rapidly growing attention of scientific institutes and …

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of
cancer. Over the past few decades, significant progress has been made in the development …

Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which
functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 …

Imbalances in protein and noncoding RNA levels in vivo lead to the occurrence of many
diseases. In addition to the use of small molecule inhibitors and agonists to restore these …

Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation
therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is …

Proteolysis targeting chimera (PROTAC) technology has become a powerful strategy in drug
discovery, especially for undruggable targets/proteins. A typical PROTAC degrader consists …

Ubiquitin (Ub) and ubiquitin-like (Ubl) pathways are critical post-translational modifications
that determine whether functional proteins are degraded or activated/inactivated. To date,> …