The causes of excess cardiovascular mortality associated with chronic kidney disease
(CKD) have been attributed in part to the CKD-mineral bone disorder syndrome (CKD-MBD) …

Skeletal integrity is maintained by a meticulous balance between bone resorption and bone
formation, and recent studies have revealed the essential role of canonical Wnt signaling …

Background Osteoprotegerin (OPG), sclerostin and DKK1 constitute opposite bone turnover
inhibitors, OPG inhibiting osteoclastogenesis while sclerostin and DKK1 exerting their …

Sclerostin, an osteocyte-derived inhibitor of bone formation, is linked to mineral bone
disorder. In order to validate its potential as a predictor of vascular calcification, we explored …

For more than a decade, the Wnt–β-catenin pathway has been the focus of intense basic
and clinical research in the bone field because of its importance in skeletal development …

Patients with chronic kidney disease (CKD) are at increased risk of osteoporosis and
vascular calcification. Bone demineralization and vascular mineralization go often hand in …

A healthy skeleton depends on a continuous renewal and maintenance of the bone tissue.
The process of bone remodeling is highly controlled and consists of a fine-tuned balance …

There is cumulating evidence for a contribution of Wnt signaling pathways in multiple
processes involved in atherosclerosis and vascular aging. Wnt signaling plays a role in …

Cystinosis is an autosomal recessive storage disease due to impaired transport of cystine
out of lysosomes. Since the accumulation of intracellular cystine affects all organs and …

Sclerostin is a glycoprotein involved in the regulation of bone metabolism, exclusively
secreted by osteocytes. It affects the activity of bone morphogenetic proteins (BMPs) and is …