Ischemia and post-ischemic reperfusion cause a wide array of functional and structural
alterations of mitochondria. Although mitochondrial impairment is recognized as pivotal in …

Even when reperfusion therapy is applied as early as possible, survival and quality of life
are compromised in a considerable number of patients with ST-segment elevation acute …

Background: The nitric oxide–sensitive guanylyl cyclase/cGMP-dependent protein kinase
type I signaling pathway can afford protection against the ischemia/reperfusion injury that …

Melatonin confers profound protective effect against myocardial ischemia–reperfusion injury
(MI/RI). Activation of N otch1/H airy and enhancer of split 1 (H es1) signaling also …

Adiponectin (APN) is a cardioprotective molecule. Its reduction in diabetes exacerbates
myocardial ischemia/reperfusion (MI/R) injury. Although APN administration in animals …

Objective: Due to reported modulatory effects of statins on nitric oxide synthase (NOS)
expression, we tested the hypothesis of protective effects of in vivo chronic treatment with …

Background. Coronary artery bypass grafting (CABG) with cardiopulmonary bypass elicits a
potent reperfusion injury and inflammatory response, more intense in patients with impaired …

Myocardial ischemia–reperfusion injury represents a combination of factors, namely the
intrinsic cellular response to ischemia and the extrinsic acute inflammatory response …

Disordered calcium homeostasis can lead to endoplasmic reticulum (ER) stress. Our
previous data showed that time course activation of ER stress contributes to time-related …

The phospholipid bilayer membrane that surrounds each cell in the body represents the first
and last line of defense for preserving overall cell viability. In several forms of cardiac and …