Essential tremor pathology: neurodegeneration and reorganization of neuronal connections

ED Louis, PL Faust - Nature Reviews Neurology, 2020 - nature.com
Essential tremor (ET) is the most common tremor disorder globally and is characterized by
kinetic tremor of the upper limbs, although other clinical features can also occur. Postmortem …

Current application of cannabidiol (CBD) in the management and treatment of neurological disorders

B Fiani, KJ Sarhadi, M Soula, A Zafar, SA Quadri - Neurological Sciences, 2020 - Springer
Cannabidiol (CBD), which is nonintoxicating pharmacologically relevant constituents of
Cannabis, demonstrates several beneficial effects. It has been found to have antioxidative …

Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

AM Brown, JJ White, ME van der Heijden, J Zhou, T Lin… - Elife, 2020 - elifesciences.org
Tremor is currently ranked as the most common movement disorder. The brain regions and
neural signals that initiate the debilitating shakiness of different body parts remain unclear …

Essential tremor: clinical perspectives and pathophysiology

MK Pan, SH Kuo - Journal of the neurological sciences, 2022 - Elsevier
Essential tremor (ET) is one of the most common neurological disorders and can be highly
disabling. In recent years, studies on the clinical perspectives and pathophysiology have …

Interactions between purkinje cells and granule cells coordinate the development of functional cerebellar circuits

ME van der Heijden, RV Sillitoe - Neuroscience, 2021 - Elsevier
Cerebellar development has a remarkably protracted morphogenetic timeline that is
coordinated by multiple cell types. Here, we discuss the intriguing cellular consequences of …

[HTML][HTML] Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities

N Mohammadzadeh, S Mehri… - Iranian journal of basic …, 2017 - ncbi.nlm.nih.gov
Berberis vulgaris L (B. vulgaris) and its main constituent berberine have been used in
traditional medicine for a long time. This medicinal plant and berberine have many …

[HTML][HTML] The olivary hypothesis of essential tremor: time to lay this model to rest?

ED Louis, A Lenka - Tremor and other hyperkinetic movements, 2017 - ncbi.nlm.nih.gov
Background Although essential tremor (ET) is the most common tremor disorder, its
pathogenesis is not fully understood. The traditional model of ET, proposed in the early …

Pharmacotherapy of essential tremor

P Hedera, FE Cibulčík, TL Davis - Journal of Central nervous …, 2013 - journals.sagepub.com
Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly
understood. This has limited the development of effective pharmacotherapy. The current …

Climbing fiber-Purkinje cell synaptic pathology in tremor and cerebellar degenerative diseases

SH Kuo, CY Lin, J Wang, PA Sims, MK Pan, J Liou… - Acta …, 2017 - Springer
Abstract Changes in climbing fiber-Purkinje cell (CF-PC) synaptic connections have been
found in the essential tremor (ET) cerebellum, and these changes are correlated with tremor …

Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and …

M Tarpley, HO Oladapo, D Strepay, TB Caligan… - European Journal of …, 2021 - Elsevier
ABSTRACT DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is
highly expressed in glioma, an aggressive brain tumor, and has been proposed as a …