Essential tremor pathology: neurodegeneration and reorganization of neuronal connections
Essential tremor (ET) is the most common tremor disorder globally and is characterized by
kinetic tremor of the upper limbs, although other clinical features can also occur. Postmortem …
kinetic tremor of the upper limbs, although other clinical features can also occur. Postmortem …
Current application of cannabidiol (CBD) in the management and treatment of neurological disorders
Cannabidiol (CBD), which is nonintoxicating pharmacologically relevant constituents of
Cannabis, demonstrates several beneficial effects. It has been found to have antioxidative …
Cannabis, demonstrates several beneficial effects. It has been found to have antioxidative …
Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation
AM Brown, JJ White, ME van der Heijden, J Zhou, T Lin… - Elife, 2020 - elifesciences.org
Tremor is currently ranked as the most common movement disorder. The brain regions and
neural signals that initiate the debilitating shakiness of different body parts remain unclear …
neural signals that initiate the debilitating shakiness of different body parts remain unclear …
Essential tremor: clinical perspectives and pathophysiology
MK Pan, SH Kuo - Journal of the neurological sciences, 2022 - Elsevier
Essential tremor (ET) is one of the most common neurological disorders and can be highly
disabling. In recent years, studies on the clinical perspectives and pathophysiology have …
disabling. In recent years, studies on the clinical perspectives and pathophysiology have …
Interactions between purkinje cells and granule cells coordinate the development of functional cerebellar circuits
ME van der Heijden, RV Sillitoe - Neuroscience, 2021 - Elsevier
Cerebellar development has a remarkably protracted morphogenetic timeline that is
coordinated by multiple cell types. Here, we discuss the intriguing cellular consequences of …
coordinated by multiple cell types. Here, we discuss the intriguing cellular consequences of …
[HTML][HTML] Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities
N Mohammadzadeh, S Mehri… - Iranian journal of basic …, 2017 - ncbi.nlm.nih.gov
Berberis vulgaris L (B. vulgaris) and its main constituent berberine have been used in
traditional medicine for a long time. This medicinal plant and berberine have many …
traditional medicine for a long time. This medicinal plant and berberine have many …
[HTML][HTML] The olivary hypothesis of essential tremor: time to lay this model to rest?
Background Although essential tremor (ET) is the most common tremor disorder, its
pathogenesis is not fully understood. The traditional model of ET, proposed in the early …
pathogenesis is not fully understood. The traditional model of ET, proposed in the early …
Pharmacotherapy of essential tremor
P Hedera, FE Cibulčík, TL Davis - Journal of Central nervous …, 2013 - journals.sagepub.com
Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly
understood. This has limited the development of effective pharmacotherapy. The current …
understood. This has limited the development of effective pharmacotherapy. The current …
Climbing fiber-Purkinje cell synaptic pathology in tremor and cerebellar degenerative diseases
Abstract Changes in climbing fiber-Purkinje cell (CF-PC) synaptic connections have been
found in the essential tremor (ET) cerebellum, and these changes are correlated with tremor …
found in the essential tremor (ET) cerebellum, and these changes are correlated with tremor …
Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and …
M Tarpley, HO Oladapo, D Strepay, TB Caligan… - European Journal of …, 2021 - Elsevier
ABSTRACT DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is
highly expressed in glioma, an aggressive brain tumor, and has been proposed as a …
highly expressed in glioma, an aggressive brain tumor, and has been proposed as a …