Lipids and Lipid Metabolism in Cellular Senescence: Emerging Targets for Age-Related Diseases

Q Zeng, YZ Gong, N Zhu, YN Shi, CJ Zhang… - Ageing Research …, 2024 - Elsevier
Cellular senescence is a kind of cellular state triggered by endogenous or exogenous
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …

Immunosenescence and macrophages: from basics to therapeutics

H Zhu, F Shen, T Liao, H Qian, Y Liu - The International Journal of …, 2023 - Elsevier
Ageing decreases the function of the immune system and increases susceptibility to some
chronic, infectious, and autoimmune diseases. Senescence cells, which produce …

Subcellular targeting strategies for protein and peptide delivery

H Su, G Rong, L Li, Y Cheng - Advanced Drug Delivery Reviews, 2024 - Elsevier
Cytosolic delivery of proteins and peptides provides opportunities for effective disease
treatment, as they can specifically modulate intracellular processes. However, most of …

From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly

H Liu, H Wang - Advanced Drug Delivery Reviews, 2024 - Elsevier
Due to the editability, functionality, and excellent biocompatibility of peptides, in situ self-
assembly of peptides in cells is a powerful strategy for biomedical applications. Subcellular …

Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐senolytics

H Zhang, X Xu, X Shou, W Liao, C Jin… - Advanced …, 2024 - Wiley Online Library
Cellular senescence is a significant risk factor for aging and age‐related diseases (ARD).
The canonical senolytics Dasatinib and Quercetin (DQ) have shown promise in clearing …

[HTML][HTML] Targeting metabolism to influence cellular senescence a promising anti-cancer therapeutic strategy

Z Wang, J Gao, C Xu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Metabolic disorders are considered the hallmarks of cancer and metabolic reprogramming is
emerging as a new strategy for cancer treatment. Exogenous and endogenous stressors can …

Penetrating efficiency of supramolecular hydrogel eye drops: Electrostatic interaction surpasses ligand-receptor interaction

Z Ren, S Li, X Liu, G Lv, L Chen, J Wang, X Li… - Chinese Chemical …, 2024 - Elsevier
The low drug bioavailability of eye drops challenges the therapy of ocular disorders with
high efficacy. One of solutions is to extend the corneal retention and enhance the …

Discovery of a self-assembling small molecule that sequesters RNA-binding proteins

H Kim, C Cui, K Toh, G Ado, T Ogawa, Y Zhang… - Chinese Chemical …, 2024 - Elsevier
Biomolecular condensates, also known as membraneless organelles, play a crucial role in
cellular organization by concentrating or sequestering biomolecules. Despite their …

Intracellular Chemical Reaction‐Induced Self‐Assembly for the Construction of Artificial Architecture and Its Functions

S Kim, G Park, D Kim, MS Hasan, C Lim… - Advanced …, 2024 - Wiley Online Library
Intracellular assemblies play vital roles in maintaining cellular functions through structural
recognition‐mediated interactions. The introduction of artificial structures has garnered …

[PDF][PDF] Senolytic Therapy Enabled by Senescent Cell-Sensitive Biomimetic Melanin Nano

H Zhang, X Xu, X Shou, W Liao, C Jin, C Chen… - bookcafe.yuntsg.com
1. Introduction 21922659, ja, Downloaded from https://onlinelibrary. wiley. com/doi/10.1002/
adhm. 202401085 by Shanghai Jiaotong University, Wiley Online Library on [29/05/2024] …