Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

Adipose tissue signals to brain, liver, and muscles to control whole body metabolism through
secreted lipid and protein factors as well as neurotransmission, but the mechanisms …

Background: Loss of brain-derived neurotrophic factor (BDNF)/TrkB (tropomyosin kinase
receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic …

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

Cardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the
spaces between cardiomyocytes following both acute and chronic tissue damage events …

Cardiac fibrosis is a common pathological consequence of most myocardial diseases. It is
associated with the excessive accumulation of extracellular matrix proteins as well as …

The two branches of the autonomic nervous system (ANS), adrenergic and cholinergic, exert
a multitude of effects on the human myocardium thanks to the activation of distinct G protein …

G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …

Chronic liver disease (CLD) has emerged as a leading cause of human deaths. It caused
1.32 million deaths in 2017, which affected men more than women by a two-to-one ratio …

Adipose tissue and its diverse cell types constitute one of the largest endocrine organs. With
multiple depot locations, adipose tissue plays an important regulatory role through paracrine …