Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators,
such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of people
worldwide. Symptom-alleviating treatments exist, although none with long-term efficacy …

Objectives: Oncostatin M (OSM), a pleiotropic cytokine and a member of the gp130/IL-6
cytokine family, has been implicated in the pathogenesis of autoimmune diseases. Here we …

Contemporary treatments for osteoarthritis (OA) pursue only to alleviate the pain caused by
the illness. Discovering disease-modifying osteoarthritis drugs (DMOADs) that can induce …

During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process.
TGF-β's signaling pathways can contribute to a hypertrophy (-like) phenotype in …

Degeneration of the intervertebral discs (IVD) is an important underlying etiology of
degenerative diseases contributor to lower back and neck pain. Alleviation of inflammation …

Osteoarthritis (OA) is a major health problem worldwide that affects the joints and causes
severe disability. It is characterized by pain and low-grade inflammation. However, the exact …

Objectives To investigate cartilage tissue turnover in response to a supervised 12-week
exercise-related joint loading training program followed by a 6-month period of …

Osteoarthritis refers to a degenerative disease with joint pain as the main symptom, and it is
caused by various factors, including fibrosis, chapping, ulcers, and loss of articular cartilage …

Aims Extracellular vesicles (EVs) are nanoparticles secreted by all cells, enriched in
proteins, lipids, and nucleic acids related to cell-to-cell communication and vital components …