Resistance to Imatinib Mesylate (IM) is a major problem in Chronic Myelogenous Leukaemia
management. Most of the studies about resistance have focused on point mutations on …

Chronic myeloid leukemia (CML) is triggered primarily by the t (9; 22)(q34. 13; q11. 23)
translocation. This reciprocal chromosomal translocation leads to the formation of the BCR …

Costunolide, a sesquiterpene lactone, is a small molecular monomer extracted from Inula
helenium (Compositae). In the present study, we assessed the antileukemia effects of …

The main objective of the study was to examine the biotransformation of the anticancer drug
imatinib in target cells by incubating it with oxidoreductases expressed in tumor cells. The …

Chronic myeloid leukemia (CML) is an oncological myeloproliferative disorder that accounts
for 15 to 20% of all adult leukemia cases. The molecular basis of this disease lies in the …

The hematopoietic neoplasm chronic myeloid leukemia (CML) is a rare disease caused by
chromosomal reciprocal translocation t (9; 22)(q34: q11) with subsequent formation of the …

Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the
presence of Bcr–Abl, a constitutively active tyrosine kinase [1]. Inhibition of Bcr–Abl with …

The development of different generations of BCR-ABL1 tyrosine kinase inhibitors (TKIs) has
led to the high overall survival of chronic myeloid leukemia (CML) patients. However, there …

Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where
mechanisms of inter-leukemic communication and cell-to-cell interactions are proposed to …

Abstract Philadelphia chromosome-positive (Ph+) leukemia is a fatal hematological
malignancy. Although standard treatments with tyrosine kinase inhibitors (TKIs) have …