[HTML][HTML] Interplay of mutations, alternate mechanisms, and treatment breaks in leukaemia: Understanding and implications studied with stochastic models
HJG Lindström, AS de Wijn, R Friedman - Computers in Biology and …, 2024 - Elsevier
Bcr-Abl1 kinase domain mutations are the most prevalent cause of treatment resistance in
chronic myeloid leukaemia (CML). Alternate resistance pathways nevertheless exist, and …
chronic myeloid leukaemia (CML). Alternate resistance pathways nevertheless exist, and …
Cellular and molecular networks in chronic myeloid leukemia: the leukemic stem, progenitor and stromal cell interplay
D Perrotti, G Silvestri, L Stramucci, J Yu… - Current drug …, 2017 - ingentaconnect.com
The use of imatinib, second and third generation ABL tyrosine kinase inhibitors (TKI)(ie
dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a …
dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a …
[HTML][HTML] Givinostat, a type II histone deacetylase inhibitor, induces potent caspase-dependent apoptosis in human lymphoblastic leukemia
Y Li, K Zhao, C Yao, S Kahwash, Y Tang… - Genes & …, 2016 - ncbi.nlm.nih.gov
Unlike chronic myeloid leukemia, patients with acute lymphoblastic leukemia (ALL) with
Philadelphia chromosome (Ph+) do not respond well to Imatinib or tyrosine kinase inhibitors …
Philadelphia chromosome (Ph+) do not respond well to Imatinib or tyrosine kinase inhibitors …
Analytical validation of the DropXpert S6 system for diagnosis of chronic myelocytic leukemia
W Wei, S Li, Y Zhang, S Deng, Q He, X Zhao, Y Xu… - Lab on a Chip, 2024 - pubs.rsc.org
Digital PCR is a powerful method for absolute nucleic acid quantification and is widely used
in the absolute quantification of viral copy numbers, tumor marker detection, and prenatal …
in the absolute quantification of viral copy numbers, tumor marker detection, and prenatal …
One more stem cell niche: how the sensitivity of chronic myeloid leukemia cells to imatinib mesylate is modulated within a “hypoxic” environment
E Rovida, I Marzi, M Grazia Cipolleschi, P Dello Sbarba - Hypoxia, 2014 - Taylor & Francis
This is a review (by no means comprehensive) of how the stem cell niche evolved from an
abstract concept to a complex system, implemented with a number of experimental data at …
abstract concept to a complex system, implemented with a number of experimental data at …
Establishment and characterization of a novel imatinib‐sensitive chronic myeloid leukemia cell line MYL, and an imatinib‐resistant subline MYL‐R showing …
T Ito, H Tanaka, A Kimura - European journal of haematology, 2007 - Wiley Online Library
In chronic myeloid leukemia (CML), resistance to imatinib is diverse. In addition to BCR‐ABL‐
dependent mechanisms, BCR‐ABL‐independent mechanisms have been proposed. Here …
dependent mechanisms, BCR‐ABL‐independent mechanisms have been proposed. Here …
[HTML][HTML] Modelling ponatinib resistance in tyrosine kinase inhibitor-naïve and dasatinib resistant BCR-ABL1+ cell lines
L Lu, CH Kok, VA Saunders, J Wang, JA McLean… - Oncotarget, 2018 - ncbi.nlm.nih.gov
TKI resistance remains a major impediment to successful treatment of CML. In this study, we
investigated the emerging modes of ponatinib resistance in TKI-naïve and dasatinib …
investigated the emerging modes of ponatinib resistance in TKI-naïve and dasatinib …
High BCR::ABL1 Expression Defines CD34+ Cells with Significant Alterations in Signal Transduction, Short-Proliferative Potential and Self-Renewal Ability
M Massimino, S Stella, E Tirrò, MS Pennisi… - OncoTargets and …, 2023 - Taylor & Francis
Purpose Chronic Myeloid Leukemia (CML) is a clonal disorder of the hematopoietic stem
cell caused by expression of the BCR:: ABL1 oncoprotein. High BCR:: ABL1 levels have …
cell caused by expression of the BCR:: ABL1 oncoprotein. High BCR:: ABL1 levels have …
Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues
JM Goldman, AR Green, T Holyoake, C Jamieson… - Leukemia, 2009 - nature.com
Ph-positive chronic myeloid leukemia (CML) and Ph-negative chronic myeloproliferative
diseases (MPDs), characterized in many cases by the presence of the JAK2 V617F …
diseases (MPDs), characterized in many cases by the presence of the JAK2 V617F …
The biology and pathogenesis of chronic myeloid leukemia
B Chereda, JV Melo - Chronic myeloid leukemia, 2016 - Springer
Chronic myeloid leukaemia (CML) is a myeloproliferative disorder of the haemopoietic stem
cell. Understanding the molecular biology of CML began with the discovery of the …
cell. Understanding the molecular biology of CML began with the discovery of the …