Coronary artery disease and acute myocardial infarction still represent the leading cause of
mortality in developed countries. Therefore, great efforts have been made in the last …

Direct contact between cellular and extracellular matrix (ECM) proteins is necessary for a
diverse array of physiologic processes including cellular activation, migration, proliferation …

Background Our objective was to determine whether abciximab, eptifibatide, or tirofiban
inhibited ligand binding to αvβ3 integrins on human aortic smooth muscle cells (HASMCs) or …

Hantaviruses infect human endothelial cells (ECs) and cause two diseases marked by
vascular permeability defects, hemorrhagic fever with renal syndrome (HFRS) and …

Abstract Matrix metalloproteinase (MMP)-2 and its hemopexin C domain autolytic fragment
(also called PEX) have been proposed to be crucial for angiogenesis. Here, we have …

α v β 3 integrins play an important role in vascular healing. Vascular injury is a stimulus for
expression of α v β 3 by vascular cells and, among other effects, α v β 3 integrins function in …

Background Identifying subjects with chronic obstructive pulmonary disease (COPD) at high
risk of exacerbation and mortality is key to aid individual management of COPD. The only …

This is the first structure of a biological homodimer of disintegrin. Disintegrins are a class of
small (4–14kDa) proteins that bind to transmembrane integrins selectively. The present …

In this study we introduce a novel in vitro'oil-drop'assay system for the measurement of
endothelial cell (EC) migration, based on the original concept of the Teflon fence assay …

In order to optimize our novel integrin αvβ3/αIIbβ3 dual antagonists, spatial screening at the
N-terminus was performed. The αvβ3 antagonistic activity varied depending on the space …