The role of the platelet glycoprotein (GP) IIIa polymorphism HPA 1b (PlA2) in the risk of
arterial thrombosis is controversial. We investigated the effect of the 1b allele on platelet …

Platelets play a significant role in coronary artery disease through interactions with each
other and with other cell types. These interactions are mediated by certain receptors on the …

Angiogenesis is a complex process consisting of the proliferation, migration and
differentiation of endothelial cells, and it is essential for the progression of malignant solid …

Soon after identification of the platelet membrane glycoprotein (GP) IIb/IIIa, it has become a
target of antiplatelet therapy. There are 3 intravenous GP IIb/IIIa receptor inhibitors, namely …

Melanomas are common neoplasms of dogs and arise from pigment-producing cells called
melanocytes or melanoblasts. Melanomas of skin are often easily cured by surgical excision …

Aberrant migration of smooth muscle cells (SMCs) is a key feature of restenosis. Since
extracellular matrix proteins and their receptors of the integrin family play a critical role in this …

Interactions between endothelial cells and extracellular matrix proteins are important
determinants of endothelial cell signaling. Endothelial adhesion to fibronectin through α v β …

The A-domains within integrin β subunits contain three metal sites termed the metal ion-
dependent adhesion site (MIDAS), site adjacent to the metal ion-dependent adhesion site …

Glioblastoma is the most prevalent malignant primary brain tumor in adults and to date
effective durable treatments are lacking. Preclinical studies underscore the importance of …

BACKGROUND AND OBJECTIVES: The physiopathogenesis of hemorrhagic phenomena in
patients with autoimmune thrombocytopenic purpura is associated with low platelet levels. In …