Mesenchymal stem cell homing to improve therapeutic efficacy in liver disease

M Yuan, X Hu, L Yao, Y Jiang, L Li - Stem Cell Research & Therapy, 2022 - Springer
Mesenchymal stem cell (MSC) transplantation, as an alternative strategy to orthotopic liver
transplantation, has been evaluated for treating end-stage liver disease. Although the …

[HTML][HTML] TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR

T Zhang, B Wang, F Su, B Gu, L Xiang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant
metastasis is a critical factor in the prognosis of patients with GC. Understanding the …

Global coagulation assays in hypercoagulable states

HY Lim, G Donnan, H Nandurkar, P Ho - Journal of thrombosis and …, 2022 - Springer
Thrombosis is one of the major global causes of morbidity and mortality, and predicting the
risk of thrombotic and cardiovascular complications remains one of the key challenges in …

Cell mediated remodeling of stiffness matched collagen and fibrin scaffolds

A Jagiełło, U Castillo, E Botvinick - Scientific reports, 2022 - nature.com
Cells are known to continuously remodel their local extracellular matrix (ECM) and in a
reciprocal way, they can also respond to mechanical and biochemical properties of their …

Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1

AA Ibrahim, T Fujimura, T Uno, T Terada… - Frontiers in …, 2024 - frontiersin.org
Background Increased levels of plasminogen activator inhibitor-1 (PAI-1) in tumors have
been found to correlate with poor clinical outcomes in patients with cancer. Although …

Cellular components contributing to the development of venous thrombosis in patients with pancreatic cancer

RAL Willems, C Biesmans, E Campello… - … in Thrombosis and …, 2023 - thieme-connect.com
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive type of cancer and has a poor
prognosis. Patients with PDAC are at high risk of developing thromboembolic events, which …

Coagulation-and fibrinolysis-related genes for predicting survival and immunotherapy efficacy in colorectal cancer

Y Ma, B Wang, P He, W Qi, L Xiang… - Frontiers in …, 2022 - frontiersin.org
Background Colorectal cancer (CRC) is a common cancer and has a poor prognosis. The
coagulation system and fibrinolysis system are closely related to the progression of …

Prospective phase II trial of prognostication by 68Ga-NOTA-AE105 uPAR PET in patients with neuroendocrine neoplasms: implications for uPAR-targeted therapy

EA Carlsen, M Loft, A Loft, AK Berthelsen… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The clinical course for patients with neuroendocrine neoplasms (NENs) ranges from
indolent to highly aggressive. Noninvasive tools to improve prognostication and guide …

Posttranscriptional regulation of the plasminogen activation system by non-coding RNA in cancer

M Alfieri, L Meo, P Ragno - International Journal of Molecular Sciences, 2023 - mdpi.com
Various species of non-coding RNAs (ncRNAs) may act as functional molecules regulating
diverse biological processes. In cancer cell biology, ncRNAs include RNAs that regulate the …

Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer

L Rinella, G Fiorentino, M Compagno, C Grange… - Cancer Gene …, 2024 - nature.com
Metastatic castration-resistant prostate cancer (mCRPC) is associated with a poor prognosis
and remains an incurable fatal disease. Therefore, the identification of molecular markers …