[HTML][HTML] PPARα/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per-and polyfluoroalkyl substances: an integrated approach

W Yang, X Ling, S He, H Cui, Z Yang, H An… - Environment …, 2023 - Elsevier
Background Per-and polyfluoroalkyl substances (PFAS) are persistent and ubiquitous
environmental contaminants with well-documented hepatotoxicity. However, the mechanistic …

Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat …

X Meng, G Yu, T Luo, R Zhang, J Zhang, Y Liu - Chemosphere, 2023 - Elsevier
Emerging epidemiological evidence indicates potential associations between gestational
perfluorobutane sulfonate (PFBS) exposure and adverse metabolic outcomes in offspring …

Prenatal exposures to endocrine disrupting chemicals: The role of multi-omics in understanding toxicity

MH Rabotnick, J Ehlinger, A Haidari… - Molecular and Cellular …, 2023 - Elsevier
Endocrine disrupting chemicals (EDCs) are a diverse group of toxicants detected in
populations globally. Prenatal EDC exposures impact birth and childhood outcomes. EDCs …

Early life exposure to low-dose perfluorooctane sulfonate disturbs gut barrier homeostasis and increases the risk of intestinal inflammation in offspring

Y Liu, G Yu, R Zhang, L Feng, J Zhang - Environmental Pollution, 2023 - Elsevier
Perfluorooctane sulfonate (PFOS), one of the legacy per-and poly-fluoroalkyl substances
(PFAS), is associated with multiple adverse health effects on children. However, much …

[HTML][HTML] Transcriptomic and metabolomic profile changes in the liver of Sprague Dawley rat offspring after maternal PFOS exposure during gestation and lactation

R Zhang, G Yu, T Luo, X Zeng, Y Sun, B Huang… - Ecotoxicology and …, 2024 - Elsevier
Epidemiological and experimental research has indicated an association between
perfluorooctane sulfonate (PFOS) exposure and liver disease. However, the potential …

[HTML][HTML] Hunting Metabolic Biomarkers for Exposure to Per-and Polyfluoroalkyl Substances: A Review

X Ma, D Cai, Q Chen, Z Zhu, S Zhang, Z Wang, Z Hu… - Metabolites, 2024 - mdpi.com
Per-and polyfluoroalkyl substances (PFAS) represent a class of persistent synthetic
chemicals extensively utilized across industrial and consumer sectors, raising substantial …

[HTML][HTML] Impact of perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA) on oxidative stress and metabolic biomarkers in human neuronal cells (SH-SY5Y)

PC Obiako, SO Ayisire, CM Sayes - Environment International, 2024 - Elsevier
Perfluorinated alkyl substances (PFAS) are pervasive environmental contaminants that have
attracted considerable attention due to their widespread utilization, resilient characteristics …

[HTML][HTML] First trimester plasma PER-AND Polyfluoroalkyl Substances (PFAS) and blood pressure trajectories across the second and third trimesters of pregnanacy

JA Burdeau, BJK Stephenson, IM Aris… - Environment …, 2024 - Elsevier
Background Evidence suggests that exposure to per-and polyfluoroalkyl substances (PFAS)
increases risk of high blood pressure (BP) during pregnancy. Prior studies did not examine …

[HTML][HTML] Insights into the effect of benzotriazoles in liver using integrated metabolomic and transcriptomic analysis

Z Guo, H Li, W Yu, Y Ren, Z Zhu - Environment International, 2024 - Elsevier
Benzotriazoles (BTRs) are a class of benzoheterocyclic chemicals that are frequently used
as metal-corrosive inhibitors, both in industry and daily use. However, the exposure effect …

Persistent metabolic toxicities following developmental exposure to hexafluoropropylene oxide trimer acid (HFPO-TA): Roles of peroxisome proliferator activated …

S Zhong, J Yuan, Y Niu, S Wang, X Gong, J Ji… - Journal of Hazardous …, 2024 - Elsevier
Background Hexafluoropropylene oxide trimer acid (HFPO-TA), a perfluorooctanoic acid
(PFOA) substitute, exhibited strong affinity and capability to activate peroxisome proliferator …