[HTML][HTML] RanGAP1 maintains chromosome stability in limb bud mesenchymal cells during bone development

M Huang, B Chen, X Chen, T Liu, S Liang, H Hu, X Bai… - Cellular …, 2024 - Elsevier
Background Bone development involves the rapid proliferation and differentiation of
osteogenic lineage cells, which makes accurate chromosomal segregation crucial for …

Signaling pathways associated with Lgr6 to regulate osteogenesis

JS King, M Wan, Y Wagley, M Stestiv, I Kalajzic… - Bone, 2024 - Elsevier
Fracture management largely relies on the bone's inherent healing capabilities and, when
necessary, surgical intervention. Currently, there are limited osteoinductive therapies to …

ADAM19 cleaves the PTH receptor and associates with brachydactyly type E

A Aydin, C Klenk, K Nemec, A Işbilir… - Life Science …, 2024 - life-science-alliance.org
Brachydactyly type E (BDE), shortened metacarpals, metatarsals, cone-shaped epiphyses,
and short stature commonly occurs as a sole phenotype. Parathyroid hormone-like protein …

Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling

F Zhong, W Hao, H Chao, Z Li, S Chen, S Li… - Biochemical and …, 2024 - Elsevier
Fractures are frequent and severe musculoskeletal injuries. This study aimed to investigate
the function of tenascin-C (TNC) in regulating chondrogenic during fracture healing and …

Metabolomics provides insights into acceleration of bone healing in fractured patients with traumatic brain injuries

D Xia, R Wu, Q Xue, G Jiang… - Biomedical …, 2023 - Wiley Online Library
While clinical surveys have frequently reported that patients with traumatic brain injuries
(TBIs) and comorbidities experience faster healing, the underlying mechanisms have been …

All-Trans Retinoic Acid-Responsive LGR6 Is Transiently Expressed during Myogenic Differentiation and Is Required for Myoblast Differentiation and Fusion

T Kitakaze, R Tatsumi, M Yamaguchi… - International Journal of …, 2023 - mdpi.com
All-trans retinoic acid (ATRA) promotes myoblast differentiation into myotubes. Leucine-rich
repeat-containing G-protein-coupled receptor 6 (LGR6) is a candidate ATRA-responsive …