Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Although the conventional activities of p53 such as cell cycle arrest, senescence, and
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …

Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Here, we identify iPLA2β as a critical regulator for p53-driven ferroptosis upon reactive
oxygen species (ROS)-induced stress. The calcium-independent phospholipase iPLA2β is …

Mutation of the TP53 tumor suppressor gene is the most common genetic alteration in
cancer, and almost 1000 alleles have been identified in human tumors. While virtually all …

Doxorubicin (DOX) is the most widely used anthracycline anticancer agent; however, its
cardiotoxicity limits its clinical efficacy. Numerous studies have elucidated the mechanisms …

The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …

Ferroptosis is a non-apoptotic form of cell death that can be triggered by inhibiting the
system xc− cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione …

Summary N 6-methyladenosine (m 6 A) of mRNAs modulated by the METTL3-METTL14-
WTAP-RBM15 methyltransferase complex and m 6 A demethylases such as FTO play …