The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage
degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are …

Destruction of articular cartilage is a key feature of a number of arthritides, osteoarthritis
prominent among them. Aggrecan degradation, caused by increased activity of proteolytic …

Purpose To determine whether the addition of a T2 mapping sequence to a routine magnetic
resonance (MR) imaging protocol could improve diagnostic performance in the detection of …

Till date, the pharmaceutical industry has failed to bring effective and safe disease modifying
osteoarthritic drugs (DMOADs) to the millions of patients suffering from this serious and …

Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic
low back pain represent the most common degenerative joint pathologies and are leading …

Simple Summary Osteoarthritis (OA), the most common joint disease affecting humans and
animals, is a painful, degenerative, and inflammatory disease that affects synovial joints and …

Osteoarthritis (OA), the most common chronic musculoskeletal disease, represents a leading
cause of disability in the elderly population worldwide. At present, there is no aetiological …

Contemporary treatments for osteoarthritis (OA) pursue only to alleviate the pain caused by
the illness. Discovering disease-modifying osteoarthritis drugs (DMOADs) that can induce …

Background Hyaline articular cartilage has limited repair and regeneration capacity.
Intraarticular administration of glucocorticoid and local anesthetic injections play an …

Osteoarthritis (OA) is the most common form of arthritis and the leading cause of chronic
disability among older people. The burden of the disease is expected to rise with an aging …