In this review, we describe the current knowledge of the biology of the JAKs. The JAK family
comprises the four nonreceptor tyrosine kinases JAK1, JAK2, JAK3, and Tyk2, all key …

During the early preclinical phase, from hit identification and optimization to a lead
compound, several medicinal chemistry strategies can be used to improve potency and/or …

Hyperuricemia (HUA) is a kind of metabolic disease with high incidence that still needs new
countermeasures. Apigenin has uric-lowering and kidney-protective activities, but how …

Abstract The structure of 4-Hydroxy-3-methoxycinnamaldehyde (4H3MC) has been
analyzed by spectroscopic and theoretical investigations. The vibrational spectral analysis of …

Abstract The IL6/JAK2/STAT3 axis dysregulation and the related downstream pathways are
a major contributor to the progression of non-small-cell lung carcinoma (NSCLC) and mainly …

Abstract Chloride channel 2 (ClC-2) is one of the nine mammalian members of the ClC
family. The present review discusses the molecular properties of ClC‑2, including CLCN2 …

The route selection and process research and development of a practical synthesis for JAK2
inhibitor LY2784544 is described. The first-generation synthesis route, similar to that used in …

Janus kinases (JAKs) are involved in a wide variety of cell signaling associated with T-cell
and B-cell mediated diseases. The pathogenesis of common lymphoid-derived diseases …

Background/Aims: Janus-activated kinase-2 JAK2 participates in the signaling of several
hormones including growth hormone, fosters tumor growth and modifies the activity of …

Compound 1, a hit from the screening of our chemical collection displaying activity against
JAK2, was deconstructed for SAR analysis into three regions, which were explored. A series …