Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel alter body
temperature (T b) in laboratory animals and humans: most cause hyperthermia; some …

Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …

Thousands of people suffer from nausea with pregnancy each year. Nausea can be
alleviated with cannabidiol (CBD), a primary component of cannabis that is widely available …

It has long been recognized that men and women have different degrees of susceptibility to
chronic pain. Greater recognition of the sexual dimorphism in chronic pain has resulted in …

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is more common
in females. Despite its high global incidence, the disease mechanism is still unclear and …

The incidence of chronic pain is especially high in women, but the underlying mechanisms
remain poorly understood. Interleukin-23 (IL-23) is a pro-inflammatory cytokine and …

This mini-review summarizes key points from the Clark Sawin Memorial Lecture on the
History of Estrogen delivered at Endo 2018 and focuses on the rationales and motivation …

Sex differences in the nervous system have gained recent academic interest. While the
prominent differences are observed in mood and anxiety disorders, growing number of …

Chronic pain is a major burden for the society and remains more prevalent and severe in
females. The presence of chronic pain is linked to persistent alterations in the peripheral and …