Alzheimer's disease (AD) is an age-related neurodegenerative disease linked with
increased production and/or deposition of amyloid-beta (Aβ) in the brain. The aim of the …

Acetylcholinesterase (AChE) is an enzyme involved in cholinergic and non-cholinergic
functions in both the central and peripheral nervous system, most of the AChE is found as a …

A series of tacrine–rhein hybrid compounds have been designed and synthesized as novel
multifunctional potent ChE inhibitors. Most of the compounds inhibited ChEs in the …

In continuing research that led us to identify a new class of carbamate derivatives acting as
potent (Rampa et al. J. Med. Chem. 1998, 41, 3976) and long-lasting (Rampa et al. J. Med …

A series of novel tacrine-isatin Schiff base hybrid derivatives (7a-p) were designed,
synthesized and evaluated as multi-target candidates against Alzheimer's disease (AD). The …

Numerous clinical and epidemiological studies have provided direct evidence to strengthen
the link between type 2 diabetes (T2D) and Alzheimer's disease (AD). The possibility that …

A series of tacrine–benzothiazole hybrids incorporate inhibitors of acetylcholinesterase
(AChE), amyloid β (Aβ) aggregation and mitochondrial enzyme ABAD, whose interaction …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing
population of elderly people. A characteristic of AD is the accumulation of plaques in the …

In this study, new derivatives of 5, 6-diphenyl triazine-thio methyl triazole hybrid were
designed, synthesized and evaluated as multifunctional agents for Alzheimer's disease …

Butyrylcholinesterase (BuChE) and amyloid β (Aβ) aggregation remain important biological
target and mechanism in the search for effective treatment of Alzheimer's disease …