The reversible inhibition of acetylcholinesterase (AChE) has become a promising target for
the treatment of Alzheimer's disease (AD) which is mainly associated with low in vivo levels …

The major protein constituent of amyloid deposits in Alzheimer's disease (AD) is the amyloid-
β-peptide (Aβ). Amyloid deposits contain “chaperone molecules” which play critical roles in …

In order to identify novel Alzheimer's modifying pharmacological tools, we developed bis-
tacrines bearing a peptide moiety for specific interference with surface sites of human …

Background Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder
that is characterized by dementia, cognitive impairment, and memory loss. Diverse factors …

Abstract A series of 1-hydroxyl-3-aminoalkoxy-thioxanthone derivatives were designed,
synthesized and evaluated as potential multifunctional agents against Alzheimer's disease …

The use of natural compounds is an interesting stratagem in the search of drugs with
therapeutic potential for the treatment of Alzheimer's disease (AD). We report here the effect …

The aim of this study was to investigate the availability of seeds, one of the byproducts of
green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of …

Novel derivatives based on 6-methyluracil and condensed uracil, 2, 4-quinazoline-2, 4-
dione, were synthesized with terminal meta-and para-benzoate moieties in polymethylene …

The cholinergic system impairment observed in Alzheimer's disease (AD) patients leads to
the cognitive, global and behavioral dysfunction commonly associated with dementia. The …

The hydrolysis of acetylthiocholine by acetylcholinesterase from Electrophorus electricus
was investigated in the presence of the inhibitors tacrine, gallamine and compound 1. The …