The numbers of patients with tuberculosis (TB) caused by resistant strains are still alarming.
Therefore, it is necessary to determine resistance more quickly and precisely, than it is with …

Drug-resistant tuberculosis (DR-TB) is still a major public health concern in South Africa.
Mutations in M. tuberculosis can cause varying levels of phenotypic resistance to anti-TB …

Objective Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a global
concern. This study aimed to determine the molecular characteristics of fluoroquinolone …

We developed a LAMP-based technique that employs primers that carry base mismatches to
specifically detect the katG (S315T) SNP associated with isoniazid resistance in tuberculosis …

Genetic variation in tuberculosis is influenced by the host environment, patients with
comorbidity, and tuberculosis–type 2 diabetes mellitus (TB-T2DM) and implies a higher risk …

Background High-dose isoniazid is recommended in the 9–12 months short-course regimen
for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient …

Background With the advancement of next generation sequencing technologies (NGS),
whole-genome sequencing (WGS) has been deployed to a wide range of clinical scenarios …

Background Type 2 diabetes mellitus (T2DM) has been associated with treatment failure,
and the development of drug resistance in tuberculosis (TB). Also, whole-genome …

Purpose: Genetic mutations in the katG and inhA promoter regions are the main drivers of
isoniazid resistance. However, the geographical distribution of isoniazid resistance …

The control of drug-resistant tuberculosis (TB) is a major challenge. The frequency and
mutation characteristics indicate the efficiency of molecular tests for the rapid detection of TB …