Genetic Influences on Alcohol Sensitivity: a Critical Review

EW Yeung, L Herchenroeder, H Webster… - Current Addiction …, 2023 - Springer
Progress in the molecular genetic study of AUD and related phenotypes is being made.
Nonetheless, significant efforts are needed to conduct GWAS of more specific AUD risk …

The role of alcohol intake in the pharmacogenetics of treatment with clozapine

N Monroy-Jaramillo, JJ Martínez-Magaña… - …, 2022 - Future Medicine
Clozapine (CLZ) is an atypical antipsychotic reserved for patients with refractory psychosis,
but it is associated with a significant risk of severe adverse reactions (ADRs) that are …

[HTML][HTML] Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information

H Gedik, TH Nguyen, RE Peterson… - Frontiers in …, 2023 - frontiersin.org
Neuropsychiatric and substance use disorders (NPSUDs) have a complex etiology that
includes environmental and polygenic risk factors with significant cross-trait genetic …

Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance

LA Greco, WR Reay, CV Dayas, MJ Cairns - Translational Psychiatry, 2022 - nature.com
Almost half of individuals diagnosed with schizophrenia also present with a substance use
disorder, however, little is known about potential molecular mechanisms underlying this …

Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data

A Quintero Reis, BA Newton, R Kessler… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of suicidal thoughts and behaviors support the
existence of genetic contributions. Continuous measures of psychiatric disorder symptom …

Causality between alcohol consumption and schizophrenia: A bidirectional Mendelian randomization study

S Liu, X Liu, Y Han, X Su, L Lv, Y Yang - 2024 - researchsquare.com
Background: Observational studies have revealed an association between alcohol
consumption and schizophrenia (SZ), and have identified high alcohol consumption as an …

Synergistic Effects of Ethanol and G-Coupled Inwardly Rectifying Potassium Channel Subunit 2 on Neuronal Excitability and Mitochondria

IA Prytkova - 2023 - search.proquest.com
Genome-wide association analysis of electroencephalographic endophenotypes for alcohol
use disorder has identified non-coding polymorphisms within the KCNJ6 gene. KCNJ6 …

[图书][B] Convergent Etiology Among Schizophrenia, Eating Disorders, and Other Medical Conditions

R Zhang - 2022 - search.proquest.com
Schizophrenia and eating disorders (EDs) are complex traits with considerable somatic
andpsychiatric morbidity. Despite distinct diagnostic criteria and few symptoms in common …